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Colon tumor

Mesenchymal tumors

Leiomyoma of colon


Reviewers: Charanjeet Singh, M.D. (see Reviewers page)
Revised: 16 May 2012, last major update May 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
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● Benign, commonly presents as incidental tumor of muscularis mucosa of colorectum
● 3% of GI leiomyomas occur in colon
● 2/3 male, median age 62 years (range 38 to 85 years)
● Benign, total excision is adequate treatment

Case reports
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● 10 month old girl with leiomyoma of the rectum (Pediatr Surg Int 2003;19:104)
● 54 year old woman with giant retroperitoneal mass (Obstet Gynecol 2003;101:1132)

Gross description
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● 4 mm, usually rectosigmoid, firm, white and well-delineated polypoid lesion

Micro description
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● Well differentiated smooth muscle cells beneath mucosa that obliterates and merges with muscularis mucosa
● May have significant atypia (symplastic leiomyoma)
● Usually no mitotic activity, no necrosis

Micro images
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Leiomyoma of muscularis mucosa


Symplastic leiomyoma

Positive stains
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● Smooth muscle actin, desmin

Negative stains
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● CD34, CD117 and S100

Additional references
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Mod Pathol 2001;14:950

End of Colon tumor > Mesenchymal tumors > Leiomyoma of colon


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