Steatocystoma simplex

Author: Deepali Jain, M.D. (see Authors page)

Revised: 24 April 2018, last major update July 2013

Copyright: (c) 2004-2018, PathologyOutlines.com, Inc.

PubMed Search: Steatocystoma simplex eye

Cite this page: Jain, D. Conjunctiva: steatocystoma simplex. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/eyesteatocytomasimplex.html. Accessed November 14th, 2018.
Definition / general
  • Rare benign adnexal tumor, usually in caruncle
  • Steatocystoma simplex if solitary; steatocystoma multiplex if multiple cysts
  • Due to nevoid malformation of pilosebaceous duct junction
  • Autosomal dominant trait in multiplex
Clinical features
  • Typically affects individuals younger than 30 years; contains yellow sebum associated with hairs
Case reports
  • Simple excision with removal of cyst wall intact
Clinical images

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Pale yellow lesion

Gross description
  • Flesh colored or yellowish, well circumscribed, soft, mobile, and non-tender
  • On incision contains oily sebum
Microscopic (histologic) description
  • Cystic space lined by nonkeratinizing squamous epithelium with an eosinophilic cuticle and sebaceous lobules within the cyst wall, but no granular layer
Microscopic (histologic) images

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Cyst lined by squamous epithelium
with sebaceous glands in cyst wall

Differential diagnosis
  • Keratinous cyst: older adults, no sebaceous glands in or adjoining wall