Joint tumors
Synovial lipomatosis

Author: Vijay Shankar, M.D. (see Authors page)

Revised: 6 September 2017, last major update June 2013

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Synovial lipomatosis

Cite this page: Shankar, V. Synovial lipomatosis. website. Accessed July 23rd, 2018.
Definition / general
  • Also called Hoffa disease, villous lipomatous proliferation of synovium, lipoma arborescens
  • Pseudotumor of synovium with distinct histomorphology, possibly due to inappropriate fat deposition and degenerative articular diseases of joints (J Lab Physicians 2011;3:84)
Clinical features
  • Rare; usually knee but may occur in any joint
  • Unknown etiology
  • Males commonly affected with pain and swelling of joint
  • Arthroscopy and excision
Gross description
  • Enlargement of infrapatellar fat pad with pain in anterior compartment of knee; synovium is papillary, yellow and fatty
Microscopic (histologic) description
  • Synovial hyperplasia with unremarkable fat extending to synovial lining; occasional chronic inflammatory infiltrate
Microscopic (histologic) images

Images hosted on other servers:

Villi-like structures

Papillary architecture

Mature adipocytes

Focal hyperplasia

Few mature lipocytes