Leukemia - Acute
B lymphoblastic leukemia / lymphoma with hypodiploidy
Reviewer: Daniela Mihova, M.D. (see Reviewers page)
Revised: 1 February 2013, last major update September 2012
Copyright: (c) 2001-2013, PathologyOutlines.com, Inc.
● Defined as fewer than 45 or 46 chromosomes
● 5% of B ALL
● 1% in both children and adults
● Most have 45 chromosomes, fewer chromosomes is rare
● Poorer prognosis: near haploid and low hypodiploid groups compared to those with 42-45 chromosomes (Br J Haematol 2004;125:552), < 44 versus 44 chromosomes (Blood 2007;110:1112) and < 45 versus 45 chromosomes (Cancer 2003;98:2715)
● Poorest prognosis: near haploid 23-29 chromosomes, which appear limited to childhood
● Overall 50% survival at 8 years
● No distinct morphology
Karyotype of severe hypodiploidy
End of Leukemia - Acute > B ALL > B lymphoblastic leukemia / lymphoma with hypodiploidy
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