Leukemia - Acute
PreB ALL
B lymphoblastic leukemia / lymphoma with hypodiploidy

Author: Daniela Mihova, M.D. (see Authors page)

Revised: 12 April 2018, last major update February 2013

Copyright: (c) 2001-2018, PathologyOutlines.com, Inc.

PubMed Search: B lymphoblastic leukemia lymphoma with hypodiploidy [title]

Cite this page: Mihova, D. B lymphoblastic leukemia / lymphoma with hypodiploidy. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/leukemiahypodiploidy.html. Accessed August 16th, 2018.
Definition / general
  • Defined as fewer than 45 or 46 chromosomes
  • 5% of B ALL
  • 1% in both children and adults
  • Most have 45 chromosomes, fewer chromosomes is rare
Prognostic factors
  • Poorer prognosis: near haploid and low hypodiploid groups compared to those with 42 - 45 chromosomes (Br J Haematol 2004;125:552), < 44 versus 44 chromosomes (Blood 2007;110:1112) and < 45 versus 45 chromosomes (Cancer 2003;98:2715)
  • Poorest prognosis: near haploid 23 - 29 chromosomes which appear limited to childhood
  • Overall 50% survival at 8 years
Microscopic (histologic) description
  • No distinct morphology
Molecular / cytogenetics images

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Karyotype of severe
hypodiploidy