Bone marrow neoplastic

Bone marrow - plasma cell and lymphoid neoplasms

B lymphoblastic leukemia / lymphoma with recurrent genetic abnormalities

with hypodiploidy



Last author update: 1 February 2013
Last staff update: 29 September 2023

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PubMed Search: B lymphoblastic leukemia lymphoma with hypodiploidy

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Cite this page: Mihova D. with hypodiploidy. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/leukemiahypodiploidy.html. Accessed May 19th, 2024.
Definition / general
  • Defined as fewer than 45 or 46 chromosomes
  • 5% of B ALL
  • 1% in both children and adults
  • Most have 45 chromosomes, fewer chromosomes is rare
Prognostic factors
  • Poorer prognosis: near haploid and low hypodiploid groups compared to those with:
  • Poorest prognosis: near haploid 23 - 29 chromosomes which appear limited to childhood
  • Overall 50% survival at 8 years
Microscopic (histologic) description
  • No distinct morphology
Molecular / cytogenetics images

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Karyotype of severe hypodiploidy

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