Bone marrow neoplastic
Bone marrow - plasma cell and lymphoid neoplasms
B lymphoblastic leukemia/lymphoma with recurrent genetic abnormalities
with hypodiploidy


Topic Completed: 1 February 2013

Minor changes: 19 June 2020

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PubMed Search: B lymphoblastic leukemia lymphoma with hypodiploidy [title]

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Cite this page: Mihova D. with hypodiploidy. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/leukemiahypodiploidy.html. Accessed August 12th, 2020.
Definition / general
  • Defined as fewer than 45 or 46 chromosomes
  • 5% of B ALL
  • 1% in both children and adults
  • Most have 45 chromosomes, fewer chromosomes is rare
Prognostic factors
  • Poorer prognosis: near haploid and low hypodiploid groups compared to those with 42 - 45 chromosomes (Br J Haematol 2004;125:552), < 44 versus 44 chromosomes (Blood 2007;110:1112) and < 45 versus 45 chromosomes (Cancer 2003;98:2715)
  • Poorest prognosis: near haploid 23 - 29 chromosomes which appear limited to childhood
  • Overall 50% survival at 8 years
Microscopic (histologic) description
  • No distinct morphology
Molecular / cytogenetics images

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Karyotype of severe
hypodiploidy
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