Table of Contents
Definition / general | Prognostic factors | Microscopic (histologic) description | Molecular / cytogenetics imagesCite this page: Mihova D. with hypodiploidy. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/leukemiahypodiploidy.html. Accessed June 4th, 2023.
Definition / general
- Defined as fewer than 45 or 46 chromosomes
- 5% of B ALL
- 1% in both children and adults
- Most have 45 chromosomes, fewer chromosomes is rare
Prognostic factors
- Poorer prognosis: near haploid and low hypodiploid groups compared to those with:
- 42 - 45 chromosomes (Br J Haematol 2004;125:552)
- < 44 versus 44 chromosomes (Blood 2007;110:1112)
- < 45 versus 45 chromosomes (Cancer 2003;98:2715)
- Poorest prognosis: near haploid 23 - 29 chromosomes which appear limited to childhood
- Overall 50% survival at 8 years
Microscopic (histologic) description
- No distinct morphology
Molecular / cytogenetics images
Images hosted on other servers:
Karyotype of severe
hypodiploidy
