Home   Chapter Home   Jobs   Conferences   Fellowships   Books



Advertisement

Liver and intrahepatic bile ducts-nontumor

Biliary tract disease

Autoimmune cholangitis


Reviewers: Komal Arora, M.D. (see Reviewers page)
Revised: 19 May 2012, last major update May 2012
Copyright: (c) 2004-2012, PathologyOutlines.com, Inc.

General
=========================================================================

● First described in 1994 (Am J Surg Pathol 1994;18:91)
● May be variant of antimitochondrial negative primary biliary cirrhosis (Dig Dis Sci 1995;40:1232, Clin Liver Dis 2004;8:177)
● May be due to IgG4 systemic disease (Clin Liver Dis 2004;8:177, J Med Case Rep 2011 Sep 28;5:485)
● More common in women
● Presents with pruritis, associated with arthralgias, sicca syndrome, Raynaud's phenomenon
Laboratory: positive antinuclear antibody, negative antimitochondrial antibody

Micro description
=========================================================================

● Ductopenia with bile duct damage similar to primary biliary cirrhosis, mild chronic active hepatitis-like portal changes, bile ductular proliferation
● Variable granulomas

Micro images
=========================================================================



Florid duct lesion with granulomatous destruction of bile duct typical of primary biliary cirrhosis


IgG4 related case

End of Liver and intrahepatic bile ducts-nontumor > Biliary tract disease > Autoimmune cholangitis


This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).