Liver and intrahepatic bile ducts - nontumor
Biliary tract disease

Topic Completed: 1 May 2012

Revised: 23 July 2019

Copyright: (c) 2002-2019,, Inc.

PubMed Search: Cholestasis[TI] liver[TI] free full text[sb]

Komal Arora, M.D.
Page views in 2018: 3,765
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Cite this page: Arora K. Cholestasis. website. Accessed August 18th, 2019.
Definition / general
  • Elevated serum alkaline phosphatase (present in bile duct epithelium and hepatocyte canalicular membrane), elevated serum bilirubin
Microscopic (histologic) description
  • Bile pigment within hepatic parenchyma (green brown bile plugs), also within Kupffer cells, foamy degeneration of hepatocytes, bile duct proliferation (proliferation of epithelial cells and looping / reduplication of ducts), concretions, periportal neutrophils
  • Late: bile lakes, portal tract fibrosis
Microscopic (histologic) images

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