Liver and intrahepatic bile ducts - nontumor
Biliary tract disease
Cholestasis




Topic Completed: 1 May 2012

Revised: 23 January 2019, last major update May 2012

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PubMed Search: Cholestasis[TI] liver[TI] free full text[sb]

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Cite this page: Arora K. Cholestasis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/livercholestasis.html. Accessed April 23rd, 2019.
Definition / general
Laboratory
  • Elevated serum alkaline phosphatase (present in bile duct epithelium and hepatocyte canalicular membrane), elevated serum bilirubin
Microscopic (histologic) description
  • Bile pigment within hepatic parenchyma (green brown bile plugs), also within Kupffer cells, foamy degeneration of hepatocytes, bile duct proliferation (proliferation of epithelial cells and looping / reduplication of ducts), concretions, periportal neutrophils
  • Late: bile lakes, portal tract fibrosis
Microscopic (histologic) images

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Cholestasis

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