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Granulomatous inflammation (non-infectious)

Hyalinizing granuloma

Reviewers: Elliot Weisenberg, M.D. (see Reviewers page)
Revised: 22 October 2014, last major update September 2011
Copyright: (c) 2003-2014, PathologyOutlines.com, Inc.


● Rare, nodular lung lesion
● Usually multiple, bilateral and cause unknown
● Inflammatory reaction of unknown stimulus
● Patients often have a history of autoimmune disease, exposure to fungal or mycobacterial antigens
● Associated with sclerosing mediastinitis, retroperitoneal fibrosis and lymphoma
● May be progressive, but does not cause death

Micro description

● Central keloid-like collagen, arranged in whorls, surrounded by foreign body giant cells simulating nodular amyloidosis
● May have plasma cells and lymphocytes between collagenous bands
● Usually no epithelioid granulomas, no necrosis

Negative stains

● Congo red

Differential diagnosis

Amyloidosis (localized), rheumatoid arthritis, silicosis
● Also infection, foreign body granuloma

End of Lung-nontumor > Granulomatous inflammation (non-infectious) > Hyalinizing granuloma

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