Lung - nontumor
Granulomatous inflammation (noninfectious)
Hyalinizing granuloma

Author: Elliot Weisenberg, M.D. (see Authors page)

Revised: 28 February 2017, last major update September 2011

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PubMed search: hyalinizing granuloma

Cite this page: Hyalinizing granuloma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/lungnontumorhyalinizinggran.html. Accessed August 21st, 2017.
Definition / general
  • Rare, nodular lung lesion
  • Usually multiple, bilateral and cause unknown
  • Inflammatory reaction of unknown stimulus
  • Patients often have a history of autoimmune disease, exposure to fungal or mycobacterial antigens
  • Associated with sclerosing mediastinitis, retroperitoneal fibrosis and lymphoma
  • May be progressive, but does not cause death
Microscopic (histologic) description
  • Central keloid-like collagen, arranged in whorls, surrounded by foreign body giant cells simulating nodular amyloidosis
  • May have plasma cells and lymphocytes between collagenous bands
  • Usually no epithelioid granulomas, no necrosis
Negative stains
Differential diagnosis