Granulomatous inflammation (non-infectious)
Reviewers: Elliot Weisenberg, M.D. (see Reviewers page)
Revised: 22 October 2014, last major update September 2011
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● Rare, nodular lung lesion
● Usually multiple, bilateral and cause unknown
● Inflammatory reaction of unknown stimulus
● Patients often have a history of autoimmune disease, exposure to fungal or mycobacterial antigens
● Associated with sclerosing mediastinitis, retroperitoneal fibrosis and lymphoma
● May be progressive, but does not cause death
● Central keloid-like collagen, arranged in whorls, surrounded by foreign body giant cells simulating nodular amyloidosis
● May have plasma cells and lymphocytes between collagenous bands
● Usually no epithelioid granulomas, no necrosis
● Congo red
● Amyloidosis (localized), rheumatoid arthritis, silicosis
● Also infection, foreign body granuloma
End of Lung-nontumor > Granulomatous inflammation (non-infectious) > Hyalinizing granuloma
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