Fetal lung type
Reviewer: Deepali Jain, M.D. (see Reviewers page)
Revised: 11 January 2013, last major update September 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.
● Rare tumor resembling fetal lung in pseudoglandular stage
● Either high grade or low grade
● May be a variant of pulmonary blastoma without malignant mesenchymal components
● Low grade tumors associated with upregulation of Wnt signaling pathway (Mod Pathol 2002;15:617)
● High grade variant is very aggressive
● Irregular tubular structures of columnar epithelial cells with clear cytoplasm and oval nuclei, optically clear nuclei rich in biotin
● Resembles fetal lung in pseudoglandular stage
● High grade: disorganized glands, large vesicular nuclei, prominent nucleoli, pronounced anisonucleosis, transition to conventional adenocarcinoma, broad areas of necrosis, desmoplastic stroma, p53+, AFP+, no morules (Am J Surg Pathol 1998;22:399)
Low grade (left), high grade (right)
Well differentiated tumor
● Low grade tumors: subnuclear vacuoles with tigroid features, small, uniform, round nuclei, morules, neuroendocrine differentiation in glandular epithelial cells (Am J Clin Pathol 2010;134:894)
End of Lung tumor > Adenocarcinoma > Fetal lung type
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