Lung tumor
Adenocarcinoma
Fetal lung type

Author: Deepali Jain, M.D. (see Authors page)

Revised: 20 December 2016, last major update September 2012

Copyright: (c) 2003-2016, PathologyOutlines.com, Inc.

PubMed Search: fetal lung type adenocarcinoma
Cite this page: Adenocarcinoma of fetal lung type. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/lungtumoradenofetal.html. Accessed November 20th, 2017.
Definition / general
  • Rare tumor resembling fetal lung in pseudoglandular stage
  • Either high grade or low grade
  • May be a variant of pulmonary blastoma without malignant mesenchymal components
  • Low grade tumors associated with upregulation of Wnt signaling pathway (Mod Pathol 2002;15:617)
  • High grade variant is very aggressive
Microscopic (histologic) description
  • Irregular tubular structures of columnar epithelial cells with clear cytoplasm and oval nuclei, optically clear nuclei rich in biotin
  • Resembles fetal lung in pseudoglandular stage
  • High grade: disorganized glands, large vesicular nuclei, prominent nucleoli, pronounced anisonucleosis, transition to conventional adenocarcinoma, broad areas of necrosis, desmoplastic stroma, p53+, AFP+, no morules (Am J Surg Pathol 1998;22:399)
Microscopic (histologic) images

Images hosted on other servers:

Well differentiated tumor

Cytology description
  • Low grade tumors: subnuclear vacuoles with tigroid features, small, uniform, round nuclei, morules, neuroendocrine differentiation in glandular epithelial cells (Am J Clin Pathol 2010;134:894)
Cytology images

Images hosted on other servers:

Various images