Lung tumor
Fetal lung type

Author: Deepali Jain, M.D. (see Authors page)

Revised: 19 July 2018, last major update September 2012

Copyright: (c) 2003-2018,, Inc.

PubMed Search: fetal lung type adenocarcinoma
Cite this page: Jain, D. Adenocarcinoma of fetal lung type. website. Accessed December 16th, 2018.
Definition / general
  • Rare tumor resembling fetal lung in pseudoglandular stage
  • Either high grade or low grade
  • May be a variant of pulmonary blastoma without malignant mesenchymal components
  • Low grade tumors associated with upregulation of Wnt signaling pathway (Mod Pathol 2002;15:617)
  • High grade variant is very aggressive
Microscopic (histologic) description
  • Irregular tubular structures of columnar epithelial cells with clear cytoplasm and oval nuclei, optically clear nuclei rich in biotin
  • Resembles fetal lung in pseudoglandular stage
  • High grade: disorganized glands, large vesicular nuclei, prominent nucleoli, pronounced anisonucleosis, transition to conventional adenocarcinoma, broad areas of necrosis, desmoplastic stroma, p53+, AFP+, no morules (Am J Surg Pathol 1998;22:399)
Microscopic (histologic) images

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Well differentiated tumor

Cytology description
  • Low grade tumors: subnuclear vacuoles with tigroid features, small, uniform, round nuclei, morules, neuroendocrine differentiation in glandular epithelial cells (Am J Clin Pathol 2010;134:894)
Cytology images

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Various images