Lung tumor
Benign tumors
Multiple pulmonary leiomyomatous hamartomas

Author: Roseann Wu, M.D., M.P.H. (see Authors page)

Revised: 8 September 2016, last major update August 2016

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PubMed Search: Multiple pulmonary leiomyomatous hamartomas

See also: Hamartoma

Cite this page: Multiple pulmonary leiomyomatous hamartomas. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/lungtumorleiomyomatoushamartomas.html. Accessed August 18th, 2018.
Definition / general
  • Proliferation of multiple smooth muscle nodules in the lung parenchyma
Essential features
  • Multiple, small, unencapsulated nodules of smooth muscle in fascicles
  • Extremely rare, with controversial relationship to benign metastasizing leiomyoma or leiomyosarcoma
Terminology
  • Controversial whether are true hamartomas or represent metastasizing leiomyoma or leiomyosarcoma
Epidemiology
  • Extremely rare, almost always asymptomatic middle aged women
Sites
  • Throughout lung parenchyma, occasionally bronchovascular distribution
Etiology
  • Possible origin from contractile system of the lung acini (contractile interstitial cell)
Clinical features
  • Usually incidental
Diagnosis
  • Biopsy of nodules
Radiology description
  • Xray: abnormal nodular shadows
  • CT: multiple small pulmonary nodules
Prognostic factors
Case reports
Treatment
  • Surveillance, enucleation or surgical removal
Gross description
  • 2 - 15 mm white, firm, solid, well demarcated nodules
Microscopic (histologic) description
  • Excessive smooth muscle bundles in fascicles, not associated with tumor
  • Spindle cells with eosinophilic, fibrillary cytoplasm and blunt, elongated nuclei
  • Scattered glands and duct-like spaces may be seen
  • No mitoses, no nuclear atypia
Microscopic (histologic) images

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Multiple pulmonary
leiomyomatous hamartomas

Positive stains
Negative stains
Differential diagnosis