Placental gross / microscopic abnormalities, nonneoplastic
Amnion nodosum

Topic Completed: 1 September 2011

Minor changes: 15 February 2019

Copyright: 2002-2019,, Inc.

PubMed Search: Amnion nodosum

Mandolin S. Ziadie, M.D.
Page views in 2019: 2,969
Page views in 2020 to date: 1,313
Cite this page: Ziadie MS. Amnion nodosum. website. Accessed June 1st, 2020.
Definition / general
  • Small deposits on fetal surface
  • Seen in placentas affected by oligohydramnios, which may be associated with fetal renal agenesis and pulmonary hypoplasia
  • May be due to desquamated skin or membrane injury
Gross description
  • Multiple yellow tan superficial amniotic lesions, 0.2 to 0.4 cm and usually near insertion of umbilical cord
Microscopic (histologic) description
  • Nodules of protuberant eosinophilic fibrinous material with entrapped squamous cells
  • Associated with stratified squamous metaplasia
Microscopic (histologic) images

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