Nonneoplastic placental conditions and abnormalities
Distal villous hyperplasia (villous dysmaturity / delayed villous maturation)

Topic Completed: 1 October 2011

Minor changes: 29 October 2020

Copyright: 2002-2020,, Inc.

PubMed Search: Distal villous hyperplasia OR villous dysmaturity OR delayed villous maturation

Mandolin S. Ziadie, M.D.
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Cite this page: Ziadie MS. Distal villous hyperplasia (villous dysmaturity / delayed villous maturation). website. Accessed November 30th, 2020.
Definition / general
  • Abnormal villous maturation associated with diabetes
  • Neonatal hepatitis should be suspected if pigment laden Hofbauer cells are present
Gross description
  • Placenta is usually large for gestational age
Microscopic (histologic) description
  • Terminal villi may be hypervascular and edematous with reduced numbers of syncytial knots
  • Trophoblast lacks normal syncytiotrophoblast
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