Placental gross / microscopic abnormalities, nonneoplastic
Distal villous hyperplasia (villous dysmaturity / delayed villous maturation)

Author: Mandolin Ziadie, M.D. (see Authors page)

Revised: 13 October 2017, last major update October 2011

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Distal villous hyperplasia OR villous dysmaturity OR delayed villous maturation

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Cite this page: Ziadie, M. Distal villous hyperplasia (villous dysmaturity / delayed villous maturation). website. Accessed January 19th, 2019.
Definition / general
  • Abnormal villous maturation associated with diabetes
  • Neonatal hepatitis should be suspected if pigment laden Hofbauer cells are present
Gross description
  • Placenta is usually large for gestational age
Microscopic (histologic) description
  • Terminal villi may be hypervascular and edematous with reduced numbers of syncytial knots
  • Trophoblast lacks normal syncytiotrophoblast