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Grossing prostate specimens

Reviewers: Komal Arora, M.D., (see Reviewers page)
Revised: 21 March 2014, last major update June 2012
Copyright: (c) 2003-2014, PathologyOutlines.com, Inc.


Needle core biopsies:
● Inking of all prostate core biopsies with colored inks, in sequential order, helps maintain specimen identity (Arch Pathol Lab Med 2009;133:295)

Radical prostatectomy: totally embed or systemic sampling (Mod Pathol 2011;24:6, International Journal of Breast Cancer 2012:2012, Article ID 932784)

Systemic sampling (12-13 blocks):
● Ink surface with 2 colors to designate left versus right
● Amputate apex and serial section parallel to urethra
● For base, thin shave or amputate and serial section parallel to urethra
● Submit base of seminal vesicles, margins of right and left vas deferens
● Serial section prostate perpendicular to urethra, submit all gross tumor (look in peripheral zone, posterior or posterior-lateral area for asymmetry in size, color, density between left and right sides)
● Special device may assist in generating sections of uniform thickness (J Magn Reson Imaging 2010;32:992)

Transurethral resection biopsies (prostate chips):
● If specimen 12 g or less, submit all
● If specimen more than 12g, submit at least 12 g
● If unsuspected carcinoma found that involves 5% or less of tissue examined, submit remaining tissue (may increase stage from T1a to T1b)
● Reference: Arch Pathol Lab Med 2006;130:936

Diagrams / clinical images

Excision can cause increase in apparent tumor stage

Device to generate uniform thickness of sections in radical prostatectomy

Whole mount sectioning


University of Denver

End of Prostate > Miscellaneous > Grossing prostate specimens

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