Skin inflammatory (nontumor)
Vesiculobullous and acantholytic reaction patterns
Transient acantholytic dermatosis (Grover disease)

Senior Author: Omar P. Sangueza, M.D.
Editorial Board Member: Robert E. LeBlanc, M.D.
Editor-in-Chief: Debra Zynger, M.D.

Topic Completed: 20 December 2018

Revised: 14 January 2019

Copyright: (c) 2019, PathologyOutlines.com, Inc.

PubMed Search: Transient acantholytic dermatosis [title]

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Cite this page: Sangueza, OP. Transient acantholytic dermatosis (Grover disease). PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/skinnontumorGrover.html. Accessed February 16th, 2019.
Definition / general
  • Transient papulovesicular eruption on the trunk
  • Sporadic, reactive condition
  • Initially characterized by Grover in 1970 (Arch Dermatol 1970;101:426)
Essential features
  • Middle aged to elderly, white, mostly male patients
  • Multiple pruritic papulovesicular eruption
  • Pathologically can mimic other vesiculobullous disease and epithelial neoplasms
  • Correlation with clinical findings is essential
Epidemiology
Sites
Etiology
Clinical features
  • Pruritic papules, papulovesicles, plaques and bullae lesions
  • Lesions distributed mainly on the trunk and proximal extremities but rarely can appear on the scalp, on the face and in the mouth (these lesions resembled aphthae)
  • No systemic symptoms
Case reports
Treatment
  • Treatment options include topical steroids, retinoids and vitamin D analogues and systemic steroids, retinoids and methotrexate
  • 5-aminolevulinic acid photodynamic therapy (ALA-PDT) shows rapid, dramatic improvement in symptoms, allowing for significant improvement in quality of life (Dermatol Surg 2013;39:960)
Clinical images

Images hosted on PathOut servers:

Contributed by
Omar P. Sangueza, M.D.

Diffuse papular erythematous eruption involving the trunk

Erythematous, keratotic papules and plaques


 Contributed by
 Mark R. Wick, M.D.

Breast skin

Microscopic (histologic) description
  • Suprabasal acantholysis with vesicle formation is the principal microscopic finding
  • Elongation of rete ridges with focal acantholysis and eosinophils may be the only early changes in Grover disease
  • Main 4 histopathological patterns are:
    • Pemphigus vulgaris / foliaceous-like: predominantly limited to suprabasal acantholysis, with basal keratinocytes attached to basement membrane forming a characteristic tombstone appearance
    • Darier-like: suprabasal acantholysis of keratinocytes with scattered apoptotic or dyskeratotic cells within various levels of the epidermis
    • Spongiotic: edema within epidermis, causing separation of keratinocytes and prominent intracellular bridges
    • Hailey-Hailey-like: suprabasal acantholysis of all levels of the epidermis without significant dyskeratosis (dilapidated brick wall appearance)
  • More than one pattern can be seen in the same setting
  • Other newly described histopathological pattern include: (Am J Dermatopathol 2010;32:541)
    • Porokeratotic: presence of oblique columns of parakeratosis over areas of epidermis devoid of granular layer, with occasional dyskeratotic cells in the upper epidermal layers and a tendency to basal vacuolization
    • Lentiginous: elongation of the rete ridges with some basal hyperpigmentation resembling a solar lentigo or Dowling-Degos disease
    • Vesicular: intraepidermal vesicles with minimal spongiosis or acantholysis on their sides
    • Lichenoid: vacuolar damage and slight lymphocytic infiltrate at the dermoepidermal junction, with occasional dyskeratosis and barely identifiable acantholysis
    • Dysmaturative: disordered keratinocyte maturation with nuclear pleomorphism and slight hyperchromasia (Am J Dermatopathol 2018;40:642)
    • Epidermolytic hyperkeratosis-like pattern (Am J Dermatopathol 2014;36:358)
Microscopic (histologic) images

Images hosted on PathOut servers:

Contributed by Omar P. Sangueza, M.D.

Suprabasal vesicle formation

Spongiotic pattern

Follicular induction

Atypical nuclei


Negative stains
Immunofluorescence description
Molecular / cytogenetics description
Differential diagnosis
Board review question #1
A white, elderly male presented with multiple pruritic papule involving the trunk. Which of the following is true regarding the diagnosis of this lesion?

  1. Associated mucosal lesion is diagnostic
  2. ATP2A2 gene abnormality is a common finding
  3. Net pattern of IgG and C3 on direct immunofluorescence
  4. Sparing of acrosyringium can be a helpful feature
Board review answer #1
D. Transient acantholytic dermatosis (Grover disease) can mimic variable vesiculobullous entities, especially pemphigus vulgaris, Darier and Hailey-Hailey. Differentiation depends on clinical presentation, microscopic findings and direct immunofluorescence findings. One microscopic finding that can help to differentiate between pemphigus vulgaris and Grover disease is adnexal structure and acrosyringium involvement in the former.

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Board review question #2
Which of the following case scenarios is typical for transient acantholytic dermatosis (Grover disease)?

  1. 17 years old male with crusted popular lesions involving head and neck
  2. 20 years old female with flaccid blisters involving the axillae and inframammary region
  3. 40 years old female with oral blisters and flaccid bullae involving the trunk
  4. 60 years old male with erythematous papule involving the trunk
Board review answer #2
D. Transient acantholytic dermatosis (Grover disease) is most common in middle aged to elderly, Caucasian men. It most commonly manifest as a vesicular eruption of the trunk.

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