Home   Chapter Home   Jobs   Conferences   Fellowships   Books



Advertisement

Skin-nontumor

Other dermatoses

Myxedema


Reviewer: Mowafak Hamodat MB.CH.B, MSc., FRCPC, Eastern Health, St. Johns (Canada) (see Reviewers page)
Revised: 1 August 2011, last major update August 2011
Copyright: (c) 2002-2011, PathologyOutlines.com, Inc.

Definition
=========================================================================

● Thick, dry, and waxy skin due to accumulation of mucopolysaccharides in dermis; similar to that in orbital tissues, caused by excess TSH secretion or hypothyroidism
● Often in pretibial skin
● Localized or generalized
Elephantiasis: extreme disease

Treatment
=========================================================================

● Self-limiting

Case reports
=========================================================================

75-year-old woman with Grave’s disease

Clinical description
=========================================================================

● Pink, yellow and waxy plaques and nodules on the antero-lateral aspect of leg
● Indurations with prominence of follicles giving rise to peau d’orange appearance, and secondary hypertrichosis is occasionally marked
● Asymptomatic or mildly pruritic

Micro description
=========================================================================

● Epidermis is hyperkeratotic, with follicular plugging, and may be papillomatous and acanthotic
● Dermis shows separation of collagen bundles by large quantities of mucin
● Satellite fibroblasts are evident, but no increase in numbers except in elephantiasis form

Positive stains
=========================================================================

● Mucicarmine, Hale’s colloidal iron, PAS+ diastase resistant

Negative stains
=========================================================================

● Direct immunofluorescence is usually negative, although granular deposits of IgM have been identified

Additional references
=========================================================================

eMedicine

End of Skin-nontumor > Other dermatoses > Myxedema


This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).