Skin-nontumor / Clinical Dermatology
Neutrophilic dermatosis associated with GI disease
Reviewer: Mowafak Hamodat, MB.CH.B, MSc., FRCPC, Eastern Health, St. Johns, Canada (see Reviewers page)
Revised: 16 December 2014, last major update July 2011
Copyright: (c) 2002-2014, PathologyOutlines.com, Inc.
● Occurs in 14-44% of patients with Crohn's disease
● Includes pyoderma gangrenosum, erythema nodosum and so-called metastatic Crohn's disease / non-necrotizing sarcoid-like granulomatous dermatitis (Hum Pathol 2003;34:1185)
● Above are all associated with vascular injury, typically with prominent extravascular neutrophilic or histiocytic dermal infiltrate
● No microbes found in skin lesions
● Immunosuppressive therapy
● Variable dermal edema and neutrophilic dermatosis
● Perivascular and interstitial neutrophilic infiltrate
● Variable numbers of lymphocytes and histiocytes
● Abundant karyorrhexis, resembling Sweet’s disease
● Also leukocytoclastic vasculitis and pustular vasculitis in some cases
● Inflammation often limited to dermis, but may involve subcutaneous fat, resulting in erythema nodosum or erythema nodosum like panniculitis
● Sweet's disease
● Pyoderma gangrenosum
● Rheumatoid neutrophilic dermatitis
End of Skin-nontumor / Clinical Dermatology > Other dermatoses > Neutrophilic dermatosis associated with GI disease
This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.
All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).