Skin-nontumor / Clinical dermatology
Other dermatoses
Neutrophilic dermatosis associated with GI disease

Author: Mowafak Hamodat, M.D., MB.CH.B, MSc., FRCPC (see Authors page)

Revised: 18 July 2016, last major update July 2011

Copyright: (c) 2002-2016, PathologyOutlines.com, Inc.

PubMed Search: Neutrophilic dermatosis associated with GI disease

Cite this page: Neutrophilic dermatosis associated with GI disease. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/skinnontumorneutrophilicderm.html. Accessed December 7th, 2016.
Definition / General
  • Occurs in 14 - 44% of patients with Crohn's disease
  • Includes pyoderma gangrenosum, erythema nodosum and so-called metastatic Crohn's disease / non-necrotizing sarcoid-like granulomatous dermatitis (Hum Pathol 2003;34:1185)
  • Above are all associated with vascular injury, typically with prominent extravascular neutrophilic or histiocytic dermal infiltrate
  • No microbes found in skin lesions
Treatment
  • Immunosuppressive therapy
Micro Description
  • Variable dermal edema and neutrophilic dermatosis
  • Perivascular and interstitial neutrophilic infiltrate
  • Variable numbers of lymphocytes and histiocytes
  • Abundant karyorrhexis, resembling Sweet's disease
  • Also leukocytoclastic vasculitis and pustular vasculitis in some cases
  • Inflammation often limited to dermis, but may involve subcutaneous fat, resulting in erythema nodosum or erythema nodosum like panniculitis
Differential Diagnosis