Skin inflammatory (nontumor)
Weber-Christian disease

Author: Mowafak Hamodat, M.D., MB.CH.B, MSc., FRCPC (see Authors page)

Revised: 22 October 2018, last major update August 2011

Copyright: (c) 2002-2018,, Inc.

PubMed Search: Weber-Christian disease

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Cite this page: Hamodat, M. Weber-Christian disease. website. Accessed January 19th, 2019.
Definition / general
  • Also called relapsing febrile nodular panniculitis
  • Recurring tender erythematous subcutaneous nodules of legs and trunk, usually in women, with malaise and fever
  • Some cases are associated with other disorders
  • No known risk factors
  • Females 30 - 60 years of age, although can occur in both sexes, in all ages, and rarely in infants
Microscopic (histologic) description
  • Lobular acute and subacute inflammation of subcutis with fat cell necrosis; later fibrosis and macrophages
Differential diagnosis
Additional references