Skin nontumor
Panniculitis
Weber-Christian disease
Last author update: 1 August 2011
Last staff update: 18 January 2021
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PubMed Search: Weber-Christian disease
Table of Contents
Definition / general | Epidemiology | Microscopic (histologic) description | Differential diagnosis | Additional referencesCite this page: Hamodat M. Weber-Christian disease. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/skinnontumorweberchristian.html. Accessed October 2nd, 2023.
Definition / general
- Also called relapsing febrile nodular panniculitis
- Recurring tender erythematous subcutaneous nodules of legs and trunk, usually in women, with malaise and fever
- Some cases are associated with other disorders
- No known risk factors
Epidemiology
- Females 30 - 60 years of age, although can occur in both sexes, in all ages, and rarely in infants
Microscopic (histologic) description
- Lobular acute and subacute inflammation of subcutis with fat cell necrosis; later fibrosis and macrophages
Differential diagnosis
- Alpha-1-antitrypsin deficiency panniculitis
- Chronic pancreatitis: associated with large areas of fat necrosis
- Lipogranulomatosis subcutanea: no systemic symptoms, single lesions
- Pancreatic endocrine tumors
Additional references
