Skin nontumor


Weber-Christian disease

Last author update: 1 August 2011
Last staff update: 18 January 2021

Copyright: 2002-2023,, Inc.

PubMed Search: Weber-Christian disease

Mowafak Hamodat, M.B.Ch.B., M.Sc.
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Cite this page: Hamodat M. Weber-Christian disease. website. Accessed October 2nd, 2023.
Definition / general
  • Also called relapsing febrile nodular panniculitis
  • Recurring tender erythematous subcutaneous nodules of legs and trunk, usually in women, with malaise and fever
  • Some cases are associated with other disorders
  • No known risk factors
  • Females 30 - 60 years of age, although can occur in both sexes, in all ages, and rarely in infants
Microscopic (histologic) description
  • Lobular acute and subacute inflammation of subcutis with fat cell necrosis; later fibrosis and macrophages
Differential diagnosis
Additional references
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