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Small bowel (small intestine)

Benign tumors and tumor-like conditions

Common variable immunodeficiency syndrome

Reviewer: Hanni Gulwani, M.D. (see Reviewers page)
Revised: 19 December 2012, last major update August 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
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● Primary immune defect (usually genetic) causing reduction in B cells and most immunoglobulin classes; also frequent bacterial infections (eMedicine)

Clinical features
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● Chronic diarrhea, malabsorption, recurrent GI giardiasis

Microscopic description
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● Mucosa may resemble celiac sprue or be normal, but always has reduced plasma cells and no IgA plasma cells
● May have lymphoid hyperplasia or apoptotic bodies in crypts
● Histologic patterns: lymphocytic colitis, collagenous enterocolitis, celiac disease, granulomatous disease, acute GVHD and IBD (Am J Surg Pathol 2007;31:1800)

End of Small bowel (small intestine) > Benign tumors and tumor-like conditions > Common variable immunodeficiency syndrome

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