Small bowel (small intestine)
Benign tumors and tumor-like conditions
Common variable immunodeficiency syndrome

Author: Hanni Gulwani, M.D. (see Authors page)

Revised: 16 February 2018, last major update August 2012

Copyright: (c) 2003-2018,, Inc.

PubMed Search: Common variable immunodeficiency syndrome small bowel
Cite this page: Gulwani, H. Common variable immunodeficiency syndrome. website. Accessed October 19th, 2018.
Definition / general
Clinical features
  • Chronic diarrhea, malabsorption, recurrent GI giardiasis
Case reports
Microscopic (histologic) description
  • Mucosa may resemble celiac sprue or be normal but always has reduced plasma cells and no IgA plasma cells
  • May have lymphoid hyperplasia or apoptotic bodies in crypts
  • Histologic patterns: lymphocytic colitis, collagenous enterocolitis, celiac disease, granulomatous disease, acute GVHD and IBD (Am J Surg Pathol 2007;31:1800)
Microscopic (histologic) images

Images hosted on PathOut server:

Case of the Week #398:

H&E images