Small bowel (small intestine)
Benign tumors and tumor-like conditions
Reviewer: Hanni Gulwani, M.D. (see Reviewers page)
Revised: 22 December 2012, last major update August 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.
● Brown-black pigment in lamina propria macrophages of proximal duodenum
● Also known as melanosis duodeni
● Due to iron and sulfur (J Formos Med Assoc 1995;94:632), and may be associated with oral iron intake, hypertension, diabetes or end stage renal disease (Endoscopy 2008;40:165, World J Gastroenterol 2012;18:1414)
● Not associated with laxative abuse (J Clin Gastroenterol 1988;10:127)
● Not associated with lipofuscin pigment, which is identified in melanosis coli.
● Often identified at endoscopy
● Pigment may originate in atmosphere or diet
● No known clinical significance
● 94 year old woman with GI bleed and spotty hyperpigmentation at endoscopy (Case of the Week #231)
Case of Week #231
End of Small bowel (small intestine) > Benign tumors and tumor-like conditions > Pseudomelanosis duodeni
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