Soft tissue
Adipose tissue

Author: Charanjeet Singh, M.D.

Revised: 28 January 2018, last major update June 2012

Copyright: (c) 2002-2018,, Inc.

PubMed Search: Lipomatosis [title] tissue

See also: adiposis dolorosa, multiple symmetric lipomatosis

Page views in 2018: 1,120
Page views in 2019 to date: 216
Cite this page: Singh, C. Lipomatosis. website. Accessed February 15th, 2019.
Definition / general
  • Diffuse overgrowth of mature adipose tissue
  • Rare disorder of children under 2 years or adults
  • Associated with obesity, Cushing’s disease, steroid therapy, protease inhibitors for HIV
  • Familial multiple lipomatosis: rare, usually autosomal dominant; multiple lipomas of trunk and extremities with relative sparing of the head and shoulders; due to translocation involving high-mobility-group protein isoform I-C on chromosome 12 and the lipoma preferred partner gene on chromosome 3 (An Bras Dermatol 2012;87:324)
  • Limb (may cause massive enlargement) or trunk
Case reports
  • Palliative surgical removal of excess fat
  • May recur
  • May lead to amputation of extremity due to distortion or loss of function
Gross description
  • Poorly circumscribed aggregates of normal appearing fat in subcutaneous and skeletal muscle (but not confined to muscle)
  • Does not affect nerves
Microscopic (histologic) description
  • Sheets and lobules of white adipose tissue that may infiltrate skeletal muscle
  • May involve bone
Positive stains
Additional references