Soft tissue
Adipose tissue
Lipomatosis

Author: Charanjeet Singh, M.D. (see Authors page)

Revised: 4 August 2016, last major update June 2012

Copyright: (c) 2002-2016, PathologyOutlines.com, Inc.

PubMed Search: Lipomatosis [title] tissue

See also: adiposis dolorosa, multiple symmetric lipomatosis

Definition / General
  • Diffuse overgrowth of mature adipose tissue
Epidemiology
  • Rare disorder of children under 2 years or adults
  • Associated with obesity, Cushing’s disease, steroid therapy, protease inhibitors for HIV
  • Familial multiple lipomatosis: rare, usually autosomal dominant; multiple lipomas of trunk and extremities with relative sparing of the head and shoulders; due to translocation involving high-mobility-group protein isoform I-C on chromosome 12 and the lipoma preferred partner gene on chromosome 3 (An Bras Dermatol 2012;87:324)
Sites
  • Limb (may cause massive enlargement) or trunk
Case Reports
Treatment
  • Palliative surgical removal of excess fat
  • May recur
  • May lead to amputation of extremity due to distortion or loss of function
Gross Description
  • Poorly circumscribed aggregates of normal appearing fat in subcutaneous and skeletal muscle (but not confined to muscle)
  • Does not affect nerves
Micro Description
  • Sheets and lobules of white adipose tissue that may infiltrate skeletal muscle
  • May involve bone
Positive Stains
Additional References