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Stains
Cytokeratin AE1 / AE3

Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 24 July 2013, last major update July 2013
Copyright: (c) 2002-2013, PathologyOutlines.com, Inc.

General
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Uses by pathologists
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Micro / cytology images
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Adrenocortical carcinoma: oncocytic


Ascitis fluid: metastatic alveolar rhabdomyosarcoma is negative, mesotheilal cell is internal positive control (fig c)


Bladder: lymphoepithelioma-like carcinoma


Breast: angiomyoepithelioma-malignant, epithelial component (fig C)


Breast ductal carcinoma: nodal metastases


Breast lobular carcinoma: metastasis to lymph node - H&E and AE1/AE3


Breast lobular carcinoma: metastasis to endometrial polyp


Duodenum: neuroendocrine carcinoma


Kidney: atypical angiomyolipoma (left) is negative, normal kidney (right) is positive


Liver: adenomatoid tumor (fig 3)


Lung cancer (non-small cell) associated lymph node


Lung cancer (non-small cell) associated lymph node: frozen section


Nasal cavity: small cell carcinoma (fig 1D)


Oral cavity: squamous cell carcinoma-acantholytic type


Pleura: poorly differentiated carcinoma


Pleura: sarcomatoid mesothelioma (fig A)


Retroperitoneum: schwannoma


Salivary gland: acinic cell carcinoma (left, fig 4); epithelial-myoepithelial carcinoma (middle); undifferentiated sarcoma-normal ducts (right, fig b)


Skin: normal epidermis


Skin: basal cell carcinoma metastatic to bone (fig 4)


Skin: squamous cell carcinoma-acantholytic type


Skull base chordoma


Small bowel: sarcomatoid carcinoma (fig 3a)


Soft tissue: angiosarcoma - left, fig 2; right, fig 1C


Soft tissue: benign mixed tumor (fig B)


Soft tissue: myoepithelioma fig C in both images


Soft tissue: myxoid chondrosarcoma (fig B)


Spinal cord: myxopapillary ependymoma of filum terminale


Testis: adenomatoid tumor


Testis: yolk sac tumor


Thymus: thymoma


Thyroid anaplastic carcinoma


Unknown site: squamous cell carcinoma


Vagina: mixed tumor (fig b)


Skin: squamous cell carcinoma-acantholytic type


Virtual slides
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Diffuse large B cell lymphoma (negative); positive control (? thymus)

Positive staining - normal
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Positive staining - disease
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Negative staining
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End of Stains > Cytokeratin AE1 / AE3


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