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Cytokeratin AE1 / AE3

Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 24 July 2013, last major update July 2013
Copyright: (c) 2002-2013, PathologyOutlines.com, Inc.


Uses by pathologists

Micro / cytology images

Adrenocortical carcinoma: oncocytic

Ascitis fluid: metastatic alveolar rhabdomyosarcoma is negative, mesotheilal cell is internal positive control (fig c)

Bladder: lymphoepithelioma-like carcinoma

Breast: angiomyoepithelioma-malignant, epithelial component (fig C)

Breast ductal carcinoma: nodal metastases

Breast lobular carcinoma: metastasis to lymph node - H&E and AE1/AE3

Breast lobular carcinoma: metastasis to endometrial polyp

Duodenum: neuroendocrine carcinoma

Kidney: atypical angiomyolipoma (left) is negative, normal kidney (right) is positive

Liver: adenomatoid tumor (fig 3)

Lung cancer (non-small cell) associated lymph node

Lung cancer (non-small cell) associated lymph node: frozen section

Nasal cavity: small cell carcinoma (fig 1D)

Oral cavity: squamous cell carcinoma-acantholytic type

Pleura: poorly differentiated carcinoma

Pleura: sarcomatoid mesothelioma (fig A)

Retroperitoneum: schwannoma

Salivary gland: acinic cell carcinoma (left, fig 4); epithelial-myoepithelial carcinoma (middle); undifferentiated sarcoma-normal ducts (right, fig b)

Skin: normal epidermis

Skin: basal cell carcinoma metastatic to bone (fig 4)

Skin: squamous cell carcinoma-acantholytic type

Skull base chordoma

Small bowel: sarcomatoid carcinoma (fig 3a)

Soft tissue: angiosarcoma - left, fig 2; right, fig 1C

Soft tissue: benign mixed tumor (fig B)

Soft tissue: myoepithelioma fig C in both images

Soft tissue: myxoid chondrosarcoma (fig B)

Spinal cord: myxopapillary ependymoma of filum terminale

Testis: adenomatoid tumor

Testis: yolk sac tumor

Thymus: thymoma

Thyroid anaplastic carcinoma

Unknown site: squamous cell carcinoma

Vagina: mixed tumor (fig b)

Skin: squamous cell carcinoma-acantholytic type

Virtual slides

Diffuse large B cell lymphoma (negative); positive control (? thymus)

Positive staining - normal

Positive staining - disease

Negative staining

End of Stains > Cytokeratin AE1 / AE3

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