Stains & molecular markers
ALK


Topic Completed: 1 January 2014

Minor changes: 17 September 2020

Copyright: 2003-2020, PathologyOutlines.com, Inc.

PubMed Search: ALK[title], ALK1[title]

Nat Pernick, M.D.
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Cite this page: Pernick N. ALK. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainsalk.html. Accessed September 20th, 2020.
Definition / general
  • See also NPM-ALK fusion protein
  • Anaplastic lymphoma kinase gene is at 2p23; protein is called ALK1, CD246
  • Membrane spanning tyrosine kinase receptor, member of insulin receptor family
  • Is NOT the same as Ki-1/CD30, contrary to some references
  • Interpretation: usually cytoplasmic and nuclear staining
  • References: OMIM #105590
Pathophysiology
Diagrams / tables

Images hosted on other servers:
ALK signaling

ALK signaling

Pathways in ALK+ anaplastic large cell lymphoma Pathways in ALK+ anaplastic large cell lymphoma Pathways in ALK+ anaplastic large cell lymphoma

Pathways in ALK+ anaplastic large cell lymphoma

Clinical features
Methods
Microscopic (histologic) images

Images hosted on other servers:
Anaplastic lymphoma

Anaplastic lymphoma

Anaplastic lymphoma: various images Anaplastic lymphoma: various images Anaplastic lymphoma: various images

Anaplastic lymphoma: various images

Diffuse large B cell lymphoma (fig B)

Diffuse large B cell lymphoma (fig B)

Inflammatory myofibroblastic tumor (IMT) of bladder

Inflammatory myofibroblastic tumor (IMT) of bladder


IMT of larynx<br>(fig 2C)

IMT of larynx
(fig 2C)

IMT-pelvis

IMT-pelvis

Inflammatory breast carcinoma is ALK-

Inflammatory breast carcinoma is ALK-

Neuroblastoma

Neuroblastoma

Renal cell carcinoma with ALK gene rearrangement

Renal cell carcinoma with ALK gene rearrangement

Positive staining - normal
  • Embryonic neurons of central and peripheral nervous systems, weakly positive in adult brain
  • Normal small intestine, T cells
  • Weakly positive in colon, prostate
Positive staining - tumors
Negative staining
  • Fibromatosis, GIST, nodular fasciitis and normal lymphoid tissue
Molecular / cytogenetics images

Contributed by LeicaBiosystems Amsterdam
ALK / EML4 t(2;2); inv(2)

ALK / EML4 t(2;2); inv(2)

ALK (2p23)

ALK (2p23)



Images hosted on other servers:
FISH: ALK+ large cell lymphoma

FISH: ALK+ large cell lymphoma

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