Stains
ALK


Topic Completed: 1 January 2014

Revised: 18 September 2019

Copyright: (c) 2003-2017, PathologyOutlines.com, Inc.

PubMed Search: ALK[title], ALK1[title]

Nat Pernick, M.D.
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Cite this page: Pernick N. ALK. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainsalk.html. Accessed September 22nd, 2019.
Definition / general
  • See also NPM-ALK fusion protein
  • Anaplastic lymphoma kinase gene is at 2p23; protein is called ALK1, CD246
  • Membrane spanning tyrosine kinase receptor, member of insulin receptor family
  • Is NOT the same as Ki-1/CD30, contrary to some references
  • Interpretation: usually cytoplasmic and nuclear staining
  • References: OMIM #105590
Pathophysiology
Diagrams / tables

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ALK signaling

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Pathways in ALK+ anaplastic large cell lymphoma

Clinical features
Methods
Microscopic (histologic) images

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Anaplastic lymphoma

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Anaplastic lymphoma: various images


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Diffuse large B cell lymphoma (fig B)

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Inflammatory myofibroblastic tumor (IMT) of bladder

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IMT of abdomen

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IMT of larynx
(fig 2C)


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IMT-pelvis

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Inflammatory breast carcinoma is ALK-

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Neuroblastoma

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Renal cell carcinoma with ALK gene rearrangement

Positive staining - normal
  • Embryonic neurons of central and peripheral nervous systems, weakly positive in adult brain
  • Normal small intestine, T cells
  • Weakly positive in colon, prostate
Positive staining - tumors
Negative staining
  • Fibromatosis, GIST, nodular fasciitis and normal lymphoid tissue
Molecular / cytogenetics images

Images hosted on PathOut server:

Images kindly provided by LeicaBiosystems Amsterdam:

ALK / EML4 t(2;2); inv(2)

ALK (2p23)



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FISH: ALK+ large cell lymphoma

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