Topic Completed: 1 January 2014

Revised: 20 December 2018, last major update January 2014

Copyright: (c) 2003-2017,, Inc.

PubMed Search: ALK[title], ALK1[title]

Nat Pernick, M.D.
Page views in 2018: 6,001
Page views in 2019 to date: 3,863
Cite this page: Pernick N. ALK. website. Accessed July 19th, 2019.
Definition / general
  • See also NPM-ALK fusion protein
  • Anaplastic lymphoma kinase gene is at 2p23; protein is called ALK1, CD246
  • Membrane spanning tyrosine kinase receptor, member of insulin receptor family
  • Is NOT the same as Ki-1/CD30, contrary to some references
  • Interpretation: usually cytoplasmic and nuclear staining
  • References: OMIM #105590
Diagrams / tables

ALK signaling

Pathways in ALK+ anaplastic large cell lymphoma

Clinical features
Microscopic (histologic) images

Images hosted on other servers:

Anaplastic lymphoma

Anaplastic lymphoma: various images

Diffuse large B cell lymphoma (fig B)

Inflammatory myofibroblastic tumor (IMT) of bladder

IMT of abdomen

IMT of larynx
(fig 2C)


Inflammatory breast carcinoma is ALK-


Renal cell carcinoma with ALK gene rearrangement

Positive staining - normal
  • Embryonic neurons of central and peripheral nervous systems, weakly positive in adult brain
  • Normal small intestine, T cells
  • Weakly positive in colon, prostate
Positive staining - tumors
Negative staining
  • Fibromatosis, GIST, nodular fasciitis and normal lymphoid tissue
Molecular / cytogenetics images

Images hosted on PathOut server:

Images kindly provided by LeicaBiosystems Amsterdam:

ALK / EML4 t(2;2); inv(2)

ALK (2p23)

Images hosted on other servers:

FISH: ALK+ large cell lymphoma

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