Stains
Arginase1

Author: Nat Pernick, M.D. (see Authors page)

Revised: 16 October 2015, last major update July 2013

Copyright: (c) 2003-2015, PathologyOutlines.com, Inc.

PubMed Search: Arginase 1[title]
Definition / General
  • Binuclear manganese metalloenzyme that catalyzes hydrolysis of arginine to ornithine and urea (Wikipedia)
  • Also called liver arginase
  • Critical regulator of nitric oxide synthesis and vascular function
  • Defects cause vascular disease, pulmonary disease, infectious disease, immune cell function or cancer
  • Argininemia: rare autosomal recessive disorder of urea cycle due to mutations in arginase gene; arginine is elevated in blood and cerebrospinal fluid, causes periodic hyperammonemia, associated with developmental delay, seizures, mental retardation, hypotonia, ataxia and progressive spastic quadriplegia (OMIM #207800)
Uses by Pathologists
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Hepatocellular carcinoma

HCC - nuclear and
cytoplasmic staining

Moderately differentiated HCC

Liver: benign and
hepatocellular carcinoma


Metastatic colonic
adenocarcinoma to liver

Cholangiocarcioma

Lung: TB related granulomas



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Skin

Positive Staining - Normal
  • Hepatocytes
Positive Staining - Disease