Author: Nat Pernick, M.D. (see Authors page)

Revised: 25 September 2015, last major update July 2013

Copyright: (c) 2003-2015,, Inc.

PubMed Search: Arginase 1[title]
  • Binuclear manganese metalloenzyme that catalyzes hydrolysis of arginine to ornithine and urea (Wikipedia)
  • Also called liver arginase
  • Critical regulator of nitric oxide synthesis and vascular function
  • Defects cause vascular disease, pulmonary disease, infectious disease, immune cell function or cancer
  • Argininemia: rare autosomal recessive disorder of urea cycle due to mutations in arginase gene; arginine is elevated in blood and cerebrospinal fluid, causes periodic hyperammonemia, associated with developmental delay, seizures, mental retardation, hypotonia, ataxia and progressive spastic quadriplegia (OMIM #207800)
Uses by Pathologists
Micro Images

Hepatocellular carcinoma

HCC - nuclear and
cytoplasmic staining

Moderately differentiated HCC

Liver: benign and
hepatocellular carcinoma

Metastatic colonic
adenocarcinoma to liver


Lung: TB related granulomas


Positive Staining - Normal
  • Hepatocytes
Positive Staining - Disease