Stains & CD markers

Topic Completed: 1 July 2013

Minor changes: 18 June 2021

Copyright: 2003-2021,, Inc.

PubMed Search: Arginase 1[title]

Nat Pernick, M.D.
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Cite this page: Pernick N. Arginase1. website. Accessed October 21st, 2021.
Definition / general
  • Binuclear manganese metalloenzyme that catalyzes hydrolysis of arginine to ornithine and urea (Wikipedia)
  • Also called liver arginase
  • Critical regulator of nitric oxide synthesis and vascular function
  • Defects cause vascular disease, pulmonary disease, infectious disease, immune cell function or cancer
  • Argininemia: rare autosomal recessive disorder of urea cycle due to mutations in arginase gene; arginine is elevated in blood and cerebrospinal fluid, causes periodic hyperammonemia, associated with developmental delay, seizures, intellectual disability, hypotonia, ataxia and progressive spastic quadriplegia (OMIM #207800)
Uses by pathologists
Microscopic (histologic) images

Contributed by GenomeMe

Colon (normal), clone IHC400

Liver (normal), clone IHC400

Contributed by Cell Marque Corporation

HCC - nuclear and cytoplasmic staining

Images hosted on other servers:

Hepatocellular carcinoma

Moderately differentiated HCC

Liver: benign and hepatocellular carcinoma

Metastatic colonic adenocarcinoma to liver


Lung: TB related granulomas

Positive staining - normal
  • Hepatocytes
Positive staining - disease
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