Stains & CD markers
Arginase1
Copyright: 2003-2023, PathologyOutlines.com, Inc.
PubMed Search: Arginase 1[title]
Arginase1
Author: Nat Pernick, M.D.
Last author update: 1 July 2013
Last staff update: 6 September 2022
Copyright: 2003-2023, PathologyOutlines.com, Inc.
PubMed Search: Arginase 1[title]
Table of Contents
Definition / general | Uses by pathologists | Microscopic (histologic) images | Positive staining - normal | Positive staining - disease | Negative staining - diseaseCite this page: Pernick N. Arginase1. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainsarginase1.html. Accessed June 7th, 2023.
Definition / general
- Binuclear manganese metalloenzyme that catalyzes hydrolysis of arginine to ornithine and urea (Wikipedia)
- Also called liver arginase
- Critical regulator of nitric oxide synthesis and vascular function
- Defects cause vascular disease, pulmonary disease, infectious disease, immune cell function or cancer
- Argininemia: rare autosomal recessive disorder of urea cycle due to mutations in arginase gene; arginine is elevated in blood and cerebrospinal fluid, causes periodic hyperammonemia, associated with developmental delay, seizures, intellectual disability, hypotonia, ataxia and progressive spastic quadriplegia (OMIM #207800)
Uses by pathologists
- Sensitive and specific marker of benign and malignant hepatocytes (Am J Surg Pathol 2010;34:1147)
- Help distinguish hepatocellular carcinoma from metastatic carcinoma (Diagn Pathol 2012;7:149, Am J Clin Pathol 2012;138:203), but also stains some intrahepatic cholangiocarcinomas (Oncol Lett 2011;2:1046)
Microscopic (histologic) images
Contributed by GenomeMe
Colon (normal), clone IHC400
Liver (normal), clone IHC400
Contributed by Cell Marque Corporation
HCC - nuclear and cytoplasmic staining
Images hosted on other servers:
Hepatocellular carcinoma
Moderately differentiated HCC
Liver: benign and hepatocellular carcinoma
Metastatic colonic adenocarcinoma to liver
Cholangiocarcioma
Lung: TB related granulomas
Positive staining - normal
- Hepatocytes
Positive staining - disease
- Hepatocellular carcinoma
- Granuloma-associated macrophages; lung: type II pneumocytes (FEMS Immunol Med Microbiol 2012;66:265)
- Pancreatic adenocarcinoma (13%, Cancer Cytopathol 2012;120:230)
Negative staining - disease
- Most cholangiocarcinomas (Hepat Mon 2015;15:e30336), although intrahepatic cholangiocarcinomas may be positive (Oncol Lett 2011;2:1046)
