Calretinin

Stains
Calretinin

Author: Nat Pernick, M.D.

Topic Completed: 1 December 2011

Minor changes: 14 May 2020

Copyright: 2003-2019, PathologyOutlines.com, Inc.

PubMed Search: calretinin[title]

Page views in 2019: 15,723

Page views in 2020 to date: 8,862

Table of Contents

Cite this page: Pernick N. Calretinin. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainscalretinin.html. Accessed July 8th, 2020.

Definition / general

Calcium binding protein structurally related to S100 and inhibin

Interpretation

Nuclear and cytoplasmic staining

Uses by pathologists

Differentiate (as part of a panel) epithelioid pleural mesothelioma (positive) from lung adenocarcinoma (negative, Am J Surg Pathol 2003;27:1031)
Differentiate (as part of a panel) epithelioid peritoneal mesothelioma (positive) from ovarian serous papillary carcinoma (usually negative, Am J Surg Pathol 2007;31:1139)
Differentiate reactive mesothelial cells (positive) from carcinomas (negative) in effusion cytology (Am J Clin Pathol 2001;116:709, Cytopathology 2008;19:218), ascites fluid / peritoneal lavage (Tohoku J Exp Med 2005;206:31) or pleural biopsies (Am J Surg Pathol 2007;31:914)
Differentiate (as part of a panel) mesothelioma (positive) from metastatic renal cell carcinoma (negative, Histopathology 2002;41:301)
Differentiate (as part of a panel) adrenal cortical lesions (calretinin+) from metastatic clear cell renal cell carcinoma (negative, Am J Surg Pathol 2011;35:678)
Differentiate (as part of a panel) adrenal cortical lesions (calretinin+) from pheochromocytoma (negative, Am J Surg Pathol 2010;34:423)
Differentiate (as part of a panel) ovarian Sertoli-Leydig tumors (positive) from sertoliform endometroid carcinoma (negative, Arch Pathol Lab Med 2007;131:979)
Differentiate schwannoma (strong staining) from neurofibroma (negative or weak / focal staining, Am J Clin Pathol 2004;122:552)
Differentiate olfactory neuroblastoma (calretinin+, p63-) from other sinonasal small round blue cell tumors (calretinin-, p63+, Am J Surg Pathol 2011;35:1786)
Differentiate ameloblastoma (calretinin+) from keratocystic odontogenic tumor (negative, Am J Surg Pathol 2008;32:256)
Diagnosis of Hirschsprung disease (negative staining, Mod Pathol 2009;22:1379)
Identify peritoneal invasive implants of serous borderline tumors of the ovary by lack of calretinin+ mesothelial cells (Mod Pathol 2006;19:364)
Marker for normal functional endometrial stromal cells (Pathol Res Pract 2007;203:79)

Microscopic (histologic) images

Contributed by Jijgee Munkhdelger, M.D., Ph.D. and Andrey Bychkov, M.D., Ph.D.

Epithelioid mesothelioma immunoprofile

Contributed by Sharon Bihlmeyer, M.D.

Ovarian granulosa cell tumor (adult)

Images hosted on other servers:

Mesothelioma: clear cell variant (pleura)

Mesothelioma-deciduoid variant: fig 6

Mesothelioma-sarcomatoid

Mesothelioma: various images

Adenomatoid tumor

Adrenal gland corticomedullary mixed tumor (fig C/D)

Colonic medullary carcinoma (fig E)

Granular cell tumor

Primary retroperitoneal mucinous cystadenoma (fig 7)

Serous effusions

Positive staining - normal

Adipocytes (Hum Pathol 2006;37:312), endometrial stromal cells, Leydig cells of testis
Mast cells, mesothelial cells, nerves (good positive control, Nordic)
Ovarian theca-lutein and theca interna cells, Sertoli cells (Hum Pathol 2003;34:994)

Positive staining - disease

Mesothelial hyperplasia and cysts
Mesothelioma (strong diffuse staining in almost all epithelioid and lymphohistiocytic subtypes, 57% of sarcomatoid subtypes, (Am J Surg Pathol 2007;31:711, Mod Pathol 2007;20:248)
Also ameloblastoma (stellate reticulum-like epithelium, Histopathology 2000;37:27), adenomatoid tumors (Am J Surg Pathol 2003;27:969), adrenal cortical tumors (96%, Mod Pathol 2003;16:591)
Cardiac myxoma (Am J Clin Pathol 2000;114:754), cervical mesonephric adenocarcinoma (88%, Am J Surg Pathol 2001;25:379), colonic medullary carcinoma (73%, Hum Pathol 2009;40:398), colorectal adenocarcinoma (various by tumor differentiation, Am J Surg Pathol 1999;23:701)
Desmoplastic small round cell tumors (20%, Mod Pathol 2003;16:229), FATWO (Hum Pathol 1999;30:856), granular cell tumor (Am J Clin Pathol 2003;119:259)
Lipoma and liposarcoma (Hum Pathol 2006;37:312), lung carcinoma (adenocarcinoma-11%, giant cell carcinoma-67%, large cell-38%, small cell-49%, Am J Surg Pathol 2003;27:150)
Schwannoma (Am J Clin Pathol 2004;122:552), sex cord stromal tumors (50-100%, including inhibin negative tumors, Am J Surg Pathol 2005;29:143, Am J Surg Pathol 2009;33:354)
Synovial sarcoma (most, Am J Surg Pathol 2001;25:610), thymic carcinoma and thymoma (some, Hum Pathol 2003;32:1155)

Negative staining

Adrenal medullary tumors including pheochromocytoma, mucinous cysts (Histopathology 2002;41:301), ovarian microcystic stromal tumor (Am J Surg Pathol 2009;33:367), renal cell carcinoma (usually)