Author: Nat Pernick, M.D. (see Authors page)

Revised: 6 November 2015, last major update December 2011

Copyright: (c) 2003-2015,, Inc.

PubMed Search: calretinin[title]
Definition / General
  • Calcium binding protein structurally related to S100 and inhibin
  • Nuclear and cytoplasmic staining
Uses by Pathologists
Micro Images

Images hosted on Pathout server:

Ovarian granulosa cell tumor (adult)

Images hosted on other servers:

Mesothelioma: clear cell variant (pleura)

Mesothelioma-deciduoid variant: fig 6


Mesothelioma: various images

Adenomatoid tumor

Adrenal gland corticomedullary mixed tumor (fig C/D)

Colonic wall neurons

Colonic medullary carcinoma (fig E)

Granular cell tumor

Primary retroperitoneal mucinous cystadenoma (fig 7)

Serous effusions

Images hosted on
Missing Image

Mesothelioma-deciduoid variant: fig D

Mesothelioma-epithelioid variant: left, middle-fig D; right-fig D

Mesothelium: hyperplastic mesothelium and
submesothelial stromal cells are calretinin+

Adenomatoid tumor

Adrenocortical carcinoma (fig B)

Adrenal gland pheochromocytoma is negative, but
ganglioneuromatous foci is positive (fig B)

Ovarian fibroma

Ovarian granulosa cell tumor (adult)

Ovarian serous borderline tumor: invasive implants show loss of calretinin+ mesothelial cells

Ovarian serous borderline tumor: non-invasive implants are surrounded by calretinin+ mesothelial cells

Rectal suction biopsy for Hirschsprung disease

Positive Staining - Normal
Positive Staining - Disease
Negative Staining