Stains & CD markers
Calretinin


Last author update: 22 July 2022
Last staff update: 22 July 2022

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PubMed Search: Calretinin

Nick Baniak, M.D.
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Cite this page: Baniak N. Calretinin. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainscalretinin.html. Accessed August 10th, 2022.
Definition / general
Essential features
  • Nuclear and cytoplasmic staining
  • Used primarily in the diagnosis of Hirschsprung disease and to confirm sex cord stromal or mesothelial lineage
  • Also positive in adrenal cortical lesions, mesonephric carcinoma, female adnexal tumor of probable Wolffian origin (FATWO) and STK11 adnexal tumor
Pathophysiology
Interpretation
Uses by pathologists
Microscopic (histologic) images

Contributed by Nick Baniak, M.D. and Sharon Bihlmeyer, M.D.

Sarcomatoid mesothelioma

Sarcomatoid mesothelioma (CK5)

Sarcomatoid mesothelioma (calretinin)

Ganglion cells in colon


No ganglion cells

Ovarian granulosa cell tumor (adult)

Ovarian granulosa cell tumor (adult)

Virtual slides

Images hosted on other servers:
Pedunculated nodule in the upper cutaneous lip

Rectum of newborn with Hirschsprung

Pedunculated nodule in the upper cutaneous lip

Calretinin (absence of ganglion cells)

Cytology images

Contributed by Nick Baniak, M.D.

Lung adenocarcinoma

Mesothelioma

Positive staining - normal
Positive staining - disease
Negative staining
Sample pathology report
  • Right pleura, core needle biopsy:
    • Mesothelioma
    • Immunohistochemistry performed shows the following staining profile in the lesional cells:
      • Positive: calretinin, WT1
      • Negative: TTF1, Claudin4
Board review style question #1

A pleural fluid specimen consists of abundant clusters of atypical cells. Pancytokeratin and WT1 stains are positive, while Claudin4 and BerEp4 are negative. The figure above shows a calretinin stain. What is the most appropriate statement?

  1. The biomarker result is noncontributory due to a lack of specificity
  2. The biomarker result is supportive of a lung adenocarcinoma
  3. The biomarker result is supportive of a lung squamous cell carcinoma
  4. The biomarker result is supportive of malignant mesothelioma
Board review style answer #1
D. The biomarker result is supportive of malignant mesothelioma

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