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Stains
Cytokeratin 20 (CK20, K20)

Reviewer: Kara Hamilton, M.S., Nat Pernick, M.D. (see Reviewers page)
Revised: 20 July 2013, last major update June 2009
Copyright: (c) 2002-2013, PathologyOutlines.com, Inc.

General
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Uses by pathologists
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Micro images
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Anal glands are CK20- (fig 1C) but rectal adenocarcinoma is CK20+ (fig 2)


Barretts: classic and non classic staining patterns


Cervical adenocarcinoma: intestinal type is CK20- (fig 1E)


Colonic adenocarcinoma: #1-well differentiated; #2-poorly differentiated; #3-metastatic; #4-primary (fig G) and metastatic to lung (fig H)


Colonic medullary carcinoma (fig 4)


Craniopharyngioma is CK20- (fig 1C); Rathke cleft cyst is CK20+ (fig 2C); pituitary gland pars intermedia is CK20+ (fig 3C)


Gastric epithelium (normal)


Gastric carcinoma (poorly differentiated, fig 4a)


Intestinal metaplasia of the urinary bladder (fig c); typical cystitis glandularis (fig h)


Lung: nonmucinous bronchioloalveolar carcinoma is CK20- (fig 1D)


Lung: mucinous bronchioloalveolar carcinoma is CK20+ (fig 2D)


Merkel cell carcinoma; #3-FNA


Pancreatic carcinoma (fig B, D and F)


Pancreatic ductal carcinoma is CK20- (fig 1f); adenocarcinoma of gallbladder is CK20+


PanIN lesions: CK20+ in grades 1, 2 and 3


Prostatic adenocarcinoma; #2 with positive staining of verumontanum


Rectal adenocarcinoma (fig 2)


Sinonasal adenocarcinoma: intestinal type (fig 4B)


Testicular mucinous cystadenoma is CK20+ (fig 3a), but ovarian tumor is CK20- (fig 5a)


Tubular adenocarcinoma


Urothelium (normal, fig 1B)


Urothelial papilloma (fig 2C)


Urothelial papillary neoplasm of LMP (fig 3C)


Urothelial CIS is diffusely CK20+ (fig B)


Urothelial carcinoma: #1-high grade; #2-papillary-high grade (fig 5C); #3-papillary-low grade (fig 4C); #4-CK20+ primary and nodal metastasis; #5 (CK20-, uncommon)


Contributed by Leica Microsystems, Biosystems Division:

Colon (normal): cytokeratin 20 (PW31) with intense cytoplasmic staining


Positive staining - normal
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Positive staining - not carcinoma
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Positive staining - carcinoma
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Negative staining
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End of Stains > Cytokeratin 20 (CK20, K20)


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