Stains & molecular markers
Cytokeratin 20 (CK20, K20)


Topic Completed: 1 July 2013

Minor changes: 19 October 2020

Copyright: 2003-2020, PathologyOutlines.com, Inc.

PubMed Search: CK20 [title]

Nat Pernick, M.D.
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Cite this page: Hamilton K, Pernick N. Cytokeratin 20 (CK20, K20). PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainsck20.html. Accessed October 28th, 2020.
Definition / general
  • Epithelial marker (MW 46 kDa) with restricted expression compared to CK7 (OMIM #608218)
Uses by pathologists
Microscopic (histologic) images

Contributed by Leica Microsystems (Biosystems Division)

Colon (normal):
CK20 (PW31) with
intense cytoplasmic
staining



Contributed by Andrey Bychkov, M.D., Ph.D.

Ovarian cancer

Urothelial carcinoma



Images hosted on other servers:

Colonic adenocarcinoma: #1-well differentiated; #2-poorly differentiated; #3-metastatic; #4-primary (fig G) and metastatic to lung (fig H)


PanIN lesions: CK20+ in grades 1, 2 and 3

Prostatic adenocarcinoma; #2 with positive staining of verumontanum

Tubular adenocarcinoma

Urothelial carcinoma, high grade

Positive staining - normal
Positive staining - not malignant
Positive staining - malignant
Negative staining
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