Stains
Cyclin D1 / BCL1


Topic Completed: 1 March 2013

Revised: 2 May 2019

Copyright: (c) 2003-2019, PathologyOutlines.com, Inc.

PubMed Search: Cyclin+D1[title]
Page views in 2018: 10,781
Page views in 2019 to date: 4,497
Cite this page: Pernick, N. Cyclin D1 . PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainscyclind1.html. Accessed May 23rd, 2019.
Definition / general
  • Cyclin D1 is also known as BCL1, B Cell Lymphoma #1, CCND1
  • Coded by BCL1 / PRAD1 (parathyroid adenoma 1) gene on #11q13
  • Responsible for transition to S phase by phosphorylating the retinoblastoma gene product, which releases transcription factors to initiate DNA replication
  • Overexpression promotes transformation to a malignant phenotype; overexpressed in many tumors
  • Cyclin D1 genotypes may be associated with nasopharyngeal carcinoma risk (Anticancer Res 2012;32:1093)
Uses by pathologists
  • Interpretation: nuclear stain
  • Mantle cell lymphoma: characterized by t(11;14) translocation, which places the cyclin D1 gene next to an immunoglobulin heavy chain enhancer gene; among lymphomas, cyclin D1 expression is very specific for mantle cell lymphoma; however, blastoid cases may be negative (Am J Surg Pathol 2012;36:214)
  • Parathyroid: overexpressed in 40% of parathyroid adenomas, strong staining in carcinomas
Microscopic (histologic) images

Images hosted on Pathout server:

Breast: MALT
lymphoma is
cyclin D1 negative



Images hosted on other servers:

Breast: papilloma and papillary carcinoma

Cervix: various benign and malignant lesions

Mantle cell lympoma (small bowel)

Mantle cell lympoma (axillary lymph node)


Skin: normal

Stomach: gastric or
gastroesophageal
junction
adenocarcinoma

Uterus: normal, complex hyperplasia and carcinoma

Various images

Positive staining - normal
Positive staining - disease
Board review question #1
A t(11;14) translocation that creates a CyclinD1-IgH fusion gene is associated with which of the malignancies below?

  1. Burkitt lymphoma
  2. Extranodal marginal zone lymphoma
  3. Follicular lymphoma
  4. Mantle cell lymphoma
  5. SLL / CLL
Board review answer #1
D. Mantle cell lymphoma.

  1. Incorrect: Burkitt lymphomas are associated with translocations involving the c-MYC gene on chromosome 8.
  2. Incorrect: extranodal marginal zone lymphomas are associated with the following translocations: t(11;18) (creating a MALT1-IAP2 fusion gene), t(1;14)(creating a BCL10-IgH fusion gene) and t(14;18) (creating a MALT1-IgH fusion gene).
  3. Incorrect: follicular lymphoma is associated with a t(14;18) translocation that creates a BCL2-IgH fusion gene.
  1. Incorrect: SLL / CLL is associated with trisomy 12, deletion 13q14 and deletion 11q23.


Citation: Kumar: Robbins & Cotran Pathologic Basis of Disease, Eighth Edition, 2009

Source: BoardVitals, 2/5/2014
Back to top