Author: Nat Pernick, M.D. (see Authors page)

Revised: 24 November 2015, last major update June 2005

Copyright: (c) 2003-2015,, Inc.

PubMed Search: Iron[title]

Definition / General
  • Also called hemosiderin (storage iron granules)
  • See also Hales colloidal iron
  • Perl’s method (Prussian blue stain): hydrochloric acid releases the protein bound to ferric iron, then potassium ferrocyanide binds with ferric iron to form ferric ferrocyanide, an insoluble blue compound
  • Hemosiderin may be present in areas of old hemorrhage or be deposited in tissues with iron overload
  • Hemosiderosis: stored iron does not interfere with organ function vs. hemochromatosis: iron overload associated with organ failure
Micro Images

Hemosiderin, liver, iron stain