Cite this page: Iron. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainsiron.html. Accessed October 21st, 2016.
Definition / General
- Also called hemosiderin (storage iron granules)
- See also Hales colloidal iron
- Perl’s method (Prussian blue stain): hydrochloric acid releases the protein bound to ferric iron, then potassium ferrocyanide binds with ferric iron to form ferric ferrocyanide, an insoluble blue compound
- Hemosiderin may be present in areas of old hemorrhage or be deposited in tissues with iron overload
- Hemosiderosis: stored iron does not interfere with organ function vs. hemochromatosis: iron overload associated with organ failure