Author: Nat Pernick, M.D. (see Authors page)

Revised: 10 November 2015, last major update June 2005

Copyright: (c) 2003-2015,, Inc.

PubMed Search: Kappa[title]

Definition / General
  • Type of immunoglobulin light chain
  • Kappa/lamba ratio is usually 2:1
  • Restricted expression of either kappa or lambda suggests monoclonality and a neoplastic process
Micro Images

Images hosted on Pathout server:

Primary localized laryngeal
amyloidosis (kappa-left; lambda-right)

Contributed by Leica Microsystems, Biosytems Division:
myeloma of marrow with ISH staining for kappa (left)
and lambda (right) light chains using Kappa Probe (PB0645),
Lambda Probe (PB0669) and Bond Polymer Refine Detection