Stains & molecular markers

Topic Completed: 1 June 2005

Minor changes: 3 September 2020

Copyright: 2003-2020,, Inc.

PubMed Search: Kappa[title]

Nat Pernick, M.D.
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Cite this page: Pernick N. Kappa. website. Accessed September 21st, 2020.
Definition / general
  • Type of immunoglobulin light chain
  • Kappa/lamba ratio is usually 2:1
  • Restricted expression of either kappa or lambda suggests monoclonality and a neoplastic process
Microscopic (histologic) images

Contributed by Leica Microsystems, Biosystems Division

Myeloma of marrow with ISH staining for kappa (left)
and lambda (right) light chains using Kappa Probe (PB0645),
Lambda Probe (PB0669) and Bond Polymer Refine Detection

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Image 01 Image 02