Author: Nat Pernick, M.D. (see Authors page)

Revised: 7 December 2015, last major update June 2005

Copyright: (c) 2003-2015,, Inc.

PubMed Search: RCC[title]

Page views in 2018: 3,589
Page views in 2019 to date: 587
Cite this page: RCC. website. Accessed February 16th, 2019.
Definition / general
  • Also called RCC Ma (Renal Cell Carcinoma Marker)
  • Mouse monoclonal antibody generated against crude microsomal fraction of proximal tubules from normal human kidney
  • Specific for glycoprotein in renal proximal tubular brush border
  • Sensitive and specific for primary renal cell carcinoma (Am J Surg Pathol 2001;25:1485)
  • Positive in 93% of primary and 67%-84% of metastatic renal cell carcinomas
  • Most clear cell (84%) or papillary RCCs were positive, compared to 0% to 56% of chromophobe carcinomas, 0% sarcomatoid carcinomas, 0% collecting duct carcinomas, 0% oncocytomas
Microscopic (histologic) images

Pulmonary adenocarcinoma metastasis (left) to renal cell carcinoma (right):
CK7 (2A); TTF1 (2B); RCC (2C)