Topic Completed: 1 June 2005

Minor changes: 31 August 2020

Copyright: 2003-2020,, Inc.

PubMed Search: RCC[title]

Nat Pernick, M.D.
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Table of Contents
Definition / general
Cite this page: Pernick N. RCC. website. Accessed September 21st, 2020.
Definition / general
  • Also called RCC Ma (Renal Cell Carcinoma Marker)
  • Mouse monoclonal antibody generated against crude microsomal fraction of proximal tubules from normal human kidney
  • Specific for glycoprotein in renal proximal tubular brush border
  • Sensitive and specific for primary renal cell carcinoma (Am J Surg Pathol 2001;25:1485)
  • Positive in 93% of primary and 67%-84% of metastatic renal cell carcinomas
  • Most clear cell (84%) or papillary RCCs were positive, compared to 0% to 56% of chromophobe carcinomas, 0% sarcomatoid carcinomas, 0% collecting duct carcinomas, 0% oncocytomas
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