Stains
Smoothelin



Topic Completed: 1 November 2011

Revised: 8 March 2019

Copyright: 2002-2018, PathologyOutlines.com, Inc.

PubMed Search: Smoothelin[TI]

Nat Pernick, M.D.
Page views in 2018: 552
Page views in 2019 to date: 442
Cite this page: Pernick N. Smoothelin. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainssmoothelin.html. Accessed September 18th, 2019.
Definition / general
Interpretation
  • Distinction of cytoplasmic from nuclear staining may be important
Uses by pathologists
Microscopic (histologic) images

Image hosted on other servers:

Lamina propria:
Muscularis mucosae
(arrowhead); Detrusor
muscle (arrow)

Positive staining - normal
  • Differentiated smooth muscle cells
Positive staining - disease
  • Cytoplasmic staining: benign smooth muscle tumors, GI leiomyosarcomas (24%, Am J Surg Pathol 2009;33:1795)
  • Nuclear staining: GI leiomyosarcomas (41%), GIST (22%)
Negative staining
  • Striated muscle, myofibroblasts, myoepithelial cells, pericytes
  • Negative cytoplasmic staining in dedifferentiated liposarcoma, desmoid tumor, GIST, inflammatory myofibroblastic tumor, MPNST, schwannoma
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