Stains
Smoothelin

Author: Nat Pernick, M.D. (see Authors page)

Revised: 15 December 2015, last major update November 2011

Copyright: (c) 2002-2015, PathologyOutlines.com, Inc.

Cite this page: Smoothelin. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainssmoothelin.html. Accessed December 4th, 2016.
Definition / General
Interpretation
  • Distinction of cytoplasmic from nuclear staining may be important
Uses by Pathologists
Micro Images

Image hosted on other servers:

Lamina propria: Muscularis mucosae (arrowhead); Detrusor muscle (arrow)



Images hosted on Nature.com:

Various images

Positive Staining - Normal
  • Differentiated smooth muscle cells
Positive Staining - Disease
  • Cytoplasmic staining: benign smooth muscle tumors, GI leiomyosarcomas (24%, Am J Surg Pathol 2009;33:1795
  • Nuclear staining: GI leiomyosarcomas (41%), GIST (22%)
Negative Staining
  • Striated muscle, myofibroblasts, myoepithelial cells, pericytes
  • Negative cytoplasmic staining in dedifferentiated liposarcoma, desmoid tumor, GIST, inflammatory myofibroblastic tumor, MPNST, schwannoma