Stains
Smoothelin

Author: Nat Pernick, M.D. (see Authors page)

Revised: 10 August 2018, last major update November 2011

Copyright: (c) 2002-2018, PathologyOutlines.com, Inc.

PubMed Search: Smoothelin[TI]

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Cite this page: Pernick, N. Smoothelin. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainssmoothelin.html. Accessed January 22nd, 2019.
Definition / general
Interpretation
  • Distinction of cytoplasmic from nuclear staining may be important
Uses by pathologists
Microscopic (histologic) images

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Lamina propria:
Muscularis mucosae
(arrowhead); Detrusor
muscle (arrow)

Positive staining - normal
  • Differentiated smooth muscle cells
Positive staining - disease
  • Cytoplasmic staining: benign smooth muscle tumors, GI leiomyosarcomas (24%, Am J Surg Pathol 2009;33:1795)
  • Nuclear staining: GI leiomyosarcomas (41%), GIST (22%)
Negative staining
  • Striated muscle, myofibroblasts, myoepithelial cells, pericytes
  • Negative cytoplasmic staining in dedifferentiated liposarcoma, desmoid tumor, GIST, inflammatory myofibroblastic tumor, MPNST, schwannoma