Stains & CD markers

Topic Completed: 1 November 2011

Minor changes: 12 August 2021

Copyright: 2002-2021,, Inc.

PubMed Search: Smoothelin[TI]

Nat Pernick, M.D.
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Cite this page: Pernick N. Smoothelin. website. Accessed October 24th, 2021.
Definition / general
  • Distinction of cytoplasmic from nuclear staining may be important
Uses by pathologists
Microscopic (histologic) images

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Lamina propria:
Muscularis mucosae
(arrowhead); Detrusor
muscle (arrow)

Positive staining - normal
  • Differentiated smooth muscle cells
Positive staining - disease
  • Cytoplasmic staining: benign smooth muscle tumors, GI leiomyosarcomas (24%, Am J Surg Pathol 2009;33:1795)
  • Nuclear staining: GI leiomyosarcomas (41%), GIST (22%)
Negative staining
  • Striated muscle, myofibroblasts, myoepithelial cells, pericytes
  • Negative cytoplasmic staining in dedifferentiated liposarcoma, desmoid tumor, GIST, inflammatory myofibroblastic tumor, MPNST, schwannoma
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