Hypertrophic gastropathy and enlarged mucosal folds
Zollinger-Ellison syndrome

Author: Elliot Weisenberg, M.D. (see Authors page)

Revised: 7 December 2016, last major update August 2012

Copyright: (c) 2003-2016,, Inc.

PubMed Search: Zollinger-Ellison syndrome
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Cite this page: Zollinger-Ellison syndrome. website. Accessed January 19th, 2019.
Definition / general
  • Duodenal ulceration, diarrhea and gastric gland hyperplasia caused by serum hypergastrinemia from pancreatic or duodenal neoplasm, or rarely by primary G cell hyperplasia of antral mucosa
  • Grossly and radiologically resembles Menetrier's disease
  • Associated with MEN1 syndrome and multicentric carcinoid tumors (Am J Surg Pathol 1990;14:503)
  • Intramucosal cysts in body in 70%, may give rise to fundic gland polyps, severity associated with serum gastrin levels (Hum Pathol 2000;31:140)
Gross description
  • Enlarged fundic mucosal folds with cerebriform pattern
Microscopic (histologic) description
  • Hyperplasia primarily of parietal cells in fundic glands
  • Normal antral glands and gastric pits, often increase in enterochromaffin-like cells