Stomach
Hypertrophic gastropathy and enlarged mucosal folds
Zollinger-Ellison syndrome

Author: Elliot Weisenberg, M.D. (see Authors page)

Revised: 7 December 2016, last major update August 2012

Copyright: (c) 2003-2016, PathologyOutlines.com, Inc.

PubMed Search: Zollinger-Ellison syndrome
Cite this page: Zollinger-Ellison syndrome. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stomachZE.html. Accessed December 7th, 2016.
Definition / General
  • Duodenal ulceration, diarrhea and gastric gland hyperplasia caused by serum hypergastrinemia from pancreatic or duodenal neoplasm, or rarely by primary G cell hyperplasia of antral mucosa
  • Grossly and radiologically resembles Menetrier's disease
  • Associated with MEN1 syndrome and multicentric carcinoid tumors (Am J Surg Pathol 1990;14:503)
  • Intramucosal cysts in body in 70%, may give rise to fundic gland polyps, severity associated with serum gastrin levels (Hum Pathol 2000;31:140)
Gross Description
  • Enlarged fundic mucosal folds with cerebriform pattern
Micro Description
  • Hyperplasia primarily of parietal cells in fundic glands
  • Normal antral glands and gastric pits, often increase in enterochromaffin-like cells