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Hypertrophic gastropathy and enlarged mucosal folds

Zollinger-Ellison syndrome

Reviewers: Elliot Weisenberg, M.D. (see Reviewers page)
Revised: 13 October 2012, last major update August 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.


● Duodenal ulceration, diarrhea and gastric gland hyperplasia caused by serum hypergastrinemia from pancreatic or duodenal neoplasm, or rarely by primary G cell hyperplasia of antral mucosa
● Grossly and radiologically resembles Menetrierís disease
● Associated with MEN1 syndrome and multicentric carcinoid tumors (Am J Surg Pathol 1990;14:503)
● Intramucosal cysts in body in 70%, may give rise to fundic gland polyps, severity associated with serum gastrin levels (Hum Pathol 2000;31:140)

Gross description

● Enlarged fundic mucosal folds with cerebriform pattern

Micro description

● Hyperplasia primarily of parietal cells in fundic glands
● Normal antral glands and gastric pits, often increase in enterochromaffin-like cells

End of Stomach > Hypertrophic gastropathy and enlarged mucosal folds > Zollinger-Ellison syndrome

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