Helicobacter heilmannii gastritis

Author: Elliot Weisenberg, M.D. (see Authors page)

Revised: 1 August 2018, last major update August 2012

Copyright: (c) 2003-2018,, Inc.

PubMed Search: Helicobacter heilmannii gastritis
Cite this page: Weisenberg, E. Helicobacter heilmannii gastritis. website. Accessed October 18th, 2018.
Definition / general
  • Very rare compared to H. pylori (Arch Pathol Lab Med 1995;119:1149)
  • Patients usually symptomatic with dyspepsia, epigastric pain, acid reflux
  • Associated with lymphoid hyperplasia, lymphoma, gastric carcinoma, peptic ulcer disease
  • Less severe and fewer lymphoid aggregates than H. pylori gastritis (Mod Pathol 1999;12:534)
  • More common in children; due to contact with farm animals or household pets
  • Helical, 3.5 - 7.5 microns, 0.9 microns in diameter
  • Prefers gastric antrum
  • H. felis, H. fennelliae, H. cinaedi also associated with human disease
  • Same as H. pylori
Microscopic (histologic) description
  • Long tight spirals; thicker and twice as long as H. pylori and usually visible with H&E stain
  • Changes similar to but less severe than H. pylori gastritis (lymphoid aggregates, scant neutrophils)
Positive stains
  • H. pylori (polyclonal antibody cross-reacts, but not monoclonal antibody), Warthin Starry, Steiner, Diff-Quik