Helicobacter heilmannii

Topic Completed: 1 August 2012

Minor changes: 25 October 2021

Copyright: 2003-2021,, Inc.

PubMed Search: Helicobacter heilmannii gastritis

Elliot Weisenberg, M.D.
Page views in 2020: 1,899
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Cite this page: Weisenberg E. Helicobacter heilmannii. website. Accessed November 29th, 2021.
Definition / general
  • Very rare compared to H. pylori (Arch Pathol Lab Med 1995;119:1149)
  • Patients usually symptomatic with dyspepsia, epigastric pain, acid reflux
  • Associated with lymphoid hyperplasia, lymphoma, gastric carcinoma, peptic ulcer disease
  • Less severe and fewer lymphoid aggregates than H. pylori gastritis (Mod Pathol 1999;12:534)
  • More common in children; due to contact with farm animals or household pets
  • Helical, 3.5 - 7.5 microns, 0.9 microns in diameter
  • Prefers gastric antrum
  • H. felis, H. fennelliae, H. cinaedi also associated with human disease
  • Same as H. pylori
Microscopic (histologic) description
  • Long tight spirals; thicker and twice as long as H. pylori and usually visible with H&E stain
  • Changes similar to but less severe than H. pylori gastritis (lymphoid aggregates, scant neutrophils)
Positive stains
  • H. pylori (polyclonal antibody cross-reacts, but not monoclonal antibody), Warthin Starry, Steiner, Diff-Quik
Board review style question #1

A 16 year old boy presents with dyspepsia and abdominal pain. Endoscopy shows nodular mucosa and histology (shown above) shows gastritis with prominent lymphoid aggregates and organisms on the mucosal surface (inset). What is your diagnosis?

  1. Atrophic gastritis
  2. Autoimmune gastritis
  3. Eosinophilic gastritis
  4. H. heilmannii gastritis
  5. H. pylori gastritis
Board review style answer #1
D. H. heilmannii gastritis

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Reference: Helicobacter heilmannii
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