Testicular regression syndrome

Testis and epididymis
Intersex syndromes
Testicular regression syndrome

Author: Turki Al-Hussain, M.D. (see Authors page)

Revised: 5 April 2017, last major update September 2012

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PubMed Search: "Testicular regression syndrome"

Table of Contents

Definition / general | Etiology | Microscopic (histologic) description | Microscopic (histologic) images

Cite this page: Testicular regression syndrome. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/testistesticularregression.html. Accessed July 15th, 2017.

Definition / general

Paucigonadal or agonadal individuals with male, female or ambiguous phenotype
Either:
1. No gonadal or testicular formation -OR-
2. Regression of testicular tissue with residual fibrovascular nodule (mean 1.1 cm), calcification and hemosiderin
Rudimentary epididymis and spermatic cord are present
External genitalia depends on chronology of gonadal injury

Etiology

Causes: cryptorchidism, possibly testicular infarct, infection, trauma, torsion or prenatal hormone induced atrophy due to overproduction of androgens

Microscopic (histologic) description

Regressed testis indicated by fibrosis, hemosiderin, calcification or Leydig cells near epididymis or proximal vas deferens (Arch Pathol Lab Med 2000;124:694)
Presence of only fat and connective tissue does not rule out an intraabdominal testis

Microscopic (histologic) images

Images hosted on other servers:

Various images

Left testicular remnant

Vascularized fibrous nodule

Hemosiderin and dystrophic calcification