Testis and epididymis
Intersex syndromes
Testicular regression syndrome

Author: Turki Al-Hussain, M.D. (see Authors page)

Revised: 5 April 2017, last major update September 2012

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PubMed Search: "Testicular regression syndrome"

Cite this page: Testicular regression syndrome. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/testistesticularregression.html. Accessed October 22nd, 2018.
Definition / general
  • Paucigonadal or agonadal individuals with male, female or ambiguous phenotype
  • Either:
    1. No gonadal or testicular formation -OR-
    2. Regression of testicular tissue with residual fibrovascular nodule (mean 1.1 cm), calcification and hemosiderin
  • Rudimentary epididymis and spermatic cord are present
  • External genitalia depends on chronology of gonadal injury
  • Causes: cryptorchidism, possibly testicular infarct, infection, trauma, torsion or prenatal hormone induced atrophy due to overproduction of androgens
Microscopic (histologic) description
  • Regressed testis indicated by fibrosis, hemosiderin, calcification or Leydig cells near epididymis or proximal vas deferens (Arch Pathol Lab Med 2000;124:694)
  • Presence of only fat and connective tissue does not rule out an intraabdominal testis
Microscopic (histologic) images

Images hosted on other servers:

Various images

Left testicular remnant

Vascularized fibrous nodule

Hemosiderin and dystrophic calcification