Testis and epididymis
Testicular regression syndrome

Topic Completed: 1 September 2012

Revised: 27 March 2019

Copyright: 2002-2018, PathologyOutlines.com, Inc.

PubMed Search: "Testicular regression syndrome"

Turki Al-Hussain, M.D.
Page views in 2019: 1,716
Page views in 2020 to date: 232
Cite this page: Al-Hussain T. Testicular regression syndrome. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/testistesticularregression.html. Accessed February 21st, 2020.
Definition / general
  • Paucigonadal or agonadal individuals with male, female or ambiguous phenotype
  • Either:
    1. No gonadal or testicular formation -OR-
    2. Regression of testicular tissue with residual fibrovascular nodule (mean 1.1 cm), calcification and hemosiderin
  • Rudimentary epididymis and spermatic cord are present
  • External genitalia depends on chronology of gonadal injury
  • Causes: cryptorchidism, possibly testicular infarct, infection, trauma, torsion or prenatal hormone induced atrophy due to overproduction of androgens
Microscopic (histologic) description
  • Regressed testis indicated by fibrosis, hemosiderin, calcification or Leydig cells near epididymis or proximal vas deferens (Arch Pathol Lab Med 2000;124:694)
  • Presence of only fat and connective tissue does not rule out an intraabdominal testis
Microscopic (histologic) images

Images hosted on other servers:

Various images

Left testicular remnant

Vascularized fibrous nodule

Hemosiderin and dystrophic calcification

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