Thyroid gland
Thyroid cancer
Thyroid cancer in children


Topic Completed: 1 March 2009

Revised: 29 August 2019

Copyright: 2003-2019, PathologyOutlines.com, Inc.

PubMed Search: pediatric thyroid cancer

Shahid Islam, M.D., Ph.D.
Page views in 2018: 103
Page views in 2019 to date: 120
Cite this page: Islam S. Thyroid cancer in children. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/thyroidthyroidcarcinomachildren.html. Accessed October 21st, 2019.
Definition / general
  • Papillary (80%), follicular (10 - 20%), some cases historically may have been follicular variant of papillary carcinoma or Hürthle cell neoplasms (Am J Clin Pathol 2000;114:681), medullary (5%), anaplastic (rare)
Epidemiology
Clinical features
  • Regional nodal metastases occur in 60 - 80%, distant metastases in 10 - 20% at diagnosis, often lung
Prognostic factors
Case reports
Molecular / cytogenetics description
  • RET rearrangements more common than adults, BRAF activation less common (20% versus 77% in adults, Mod Pathol 2005;18:898)
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