Chemistry, toxicology & urinalysis

Organ specific

Adrenal

Captopril suppression test



Topic Completed: 1 February 2010

Minor changes: 2 April 2020

Copyright: 2002-2021, PathologyOutlines.com, Inc.

PubMed Search: Captopril suppression test

Renu Virk, M.D.
Page views in 2020: 868
Page views in 2021 to date: 633
Cite this page: Virk R. Captopril suppression test. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/adrenalcaptopril.html. Accessed December 3rd, 2021.
Definition / general
Indication:

Rationale:
  • Captopril inhibits conversion of angiotensin I to angiotensin II, thereby decreasing aldosterone production in normal individuals
  • In patients with primary hyperaldosteronism, the plasma aldosterone levels are NOT suppressed by captopril

Methodology:
  • Measure plasma aldosterone levels at baseline and 2 hours after patient takes 25mg of captopril orally

Normal range:
  • Plasma aldosterone concentration (PAC) <15 ng/dl (416pmol.L) and PAC to plasma renin activity (PRA) ratio less than 50

Adverse effects:
  • Marked hypotension may occur due to captopril intake
  • Blood pressure should be monitored regularly
Additional references
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