Chemistry, toxicology & urinalysis

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Captopril suppression test

Topic Completed: 1 February 2010

Minor changes: 2 April 2020

Copyright: 2002-2021,, Inc.

PubMed Search: Captopril suppression test

Renu Virk, M.D.
Page views in 2020: 868
Page views in 2021 to date: 633
Cite this page: Virk R. Captopril suppression test. website. Accessed December 3rd, 2021.
Definition / general

  • Captopril inhibits conversion of angiotensin I to angiotensin II, thereby decreasing aldosterone production in normal individuals
  • In patients with primary hyperaldosteronism, the plasma aldosterone levels are NOT suppressed by captopril

  • Measure plasma aldosterone levels at baseline and 2 hours after patient takes 25mg of captopril orally

Normal range:
  • Plasma aldosterone concentration (PAC) <15 ng/dl (416pmol.L) and PAC to plasma renin activity (PRA) ratio less than 50

Adverse effects:
  • Marked hypotension may occur due to captopril intake
  • Blood pressure should be monitored regularly
Additional references
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