Anus & perianal area
Verrucous carcinoma

Topic Completed: 1 January 2015

Minor changes: 19 August 2019

Copyright: (c) 2002-2019,, Inc.

PubMed Search: Verrucous carcinoma anus

Raul S. Gonzalez, M.D.
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Cite this page: Gonzalez RS. Verrucous carcinoma. website. Accessed March 8th, 2021.
Definition / general
  • Uncommon lower grade variant of squamous cell carcinoma
  • Considered intermediate between condyloma acuminatum and squamous cell carcinoma
  • Giant condyloma acuminatum / Buschke-Löwenstein tumor: may represent the same entity or spectrum of disease (Histopathology 1985;9:1155)
  • Large condyloma acuminatum term has been proposed for tumors 2 - 10 cm, with "giant" referring to those > 10 cm (Mod Pathol 2008;21:112A)
  • More common in men
Clinical features
  • Large anal tumor (often > 10 cm) that may be accompanied by abscess or fistula
  • Often will recur but does not metastasize; mortality is approximately 20% (Dis Colon Rectum 1994;37:950)
Case reports
Gross description
  • Polypoid; resembles a condyloma but is larger
Microscopic (histologic) description
  • Very well differentiated squamous malignancy with minimal atypia and pushing borders
  • Locally destructive, without obvious invasive features, lymphovascular invasion etc.
  • Can exhibit surface maturation and extensive keratinization
  • May transform into conventional squamous cell carcinoma; rate of such transformation may be dependent on tumor size
  • Similar to verrucous carcinoma at other sites
Differential diagnosis
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