Other invasive carcinoma subtypes, WHO classified

Mixed NST

Last author update: 1 August 2012
Last staff update: 1 August 2023 (update in progress)

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PubMed search: ductal [title] AND lobular [title] carcinoma breast

Monika Roychowdhury, M.D.
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Cite this page: Roychowdhury M. Mixed NST. website. Accessed September 30th, 2023.
Definition / general
  • Mixture of ductal carcinoma NOS and lobular carcinoma
  • Not part of WHO breast classification
Clinical features
  • Age of onset similar to infiltrating ductal carcinoma
  • Survival similar to pure ductal or lobular types
  • Compared to pure ductal carcinomas, have higher rate of second primary breast cancers (World J Surg Oncol 2010;8:51, Breast Cancer Res Treat 2009;114:243)
  • Compared to pure lobular carcinomas, have lower rate of synchronous contralateral breast cancer
  • 4% of breast carcinomas
  • 89% have DCIS, 31% have LCIS
  • 41% have positive lymph nodes at diagnosis
  • May have higher plasma levels of Soluble human leukocyte antigen s(HLA)-G (Anticancer Res 2012;32:1021)
Microscopic (histologic) description
  • Definite features of invasive ductal carcinoma and invasive lobular carcinoma in same tumor
Microscopic (histologic) images

Images hosted on other servers:

Mixed ductal / lobular tumor

E-cadherin immunostaining of ductal components of tumor

Positive stains
Differential diagnosis
  • Tubulolobular carcinoma: typical areas of invasive lobular carcinoma with cords of single file cells, which merge with small round to angulated tubules with minute or undetectable lumina
  • Collision of two separate neoplasms
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