CD Markers
CD138
Copyright: 2002-2023, PathologyOutlines.com, Inc.
PubMed Search: CD138[title]
CD138
Author: Nat Pernick, M.D.
Last author update: 1 February 2002
Last staff update: 15 August 2022
Copyright: 2002-2023, PathologyOutlines.com, Inc.
PubMed Search: CD138[title]
Table of Contents
Definition / general | Interpretation | Microscopic (histologic) images | Positive staining - normal | Positive staining - tumors | Negative staining | Additional referencesCite this page: Pernick N. CD138. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd138.html. Accessed May 29th, 2023.
Definition / general
- Aka heparan sulfate proteoglycan, syndecan-1
- Mediates cell adhesion, growth factors; associated with late stage of B cell differentiation
- Integral membrane protein is a receptor for extracellular matrix
- Loss of CD138 expression is associated with tumor aggressiveness in squamous cell carcinoma (SCC) of head and neck and larynx; levels also reduced in invasive SCC but not in SCC in situ
Interpretation
- Membranous staining
Microscopic (histologic) images
Contributed by Yuri Tachibana, M.D.
Chronic endometritis
Positive staining - normal
- B cell precursors, plasma cells, stratified squamous epithelium
Positive staining - tumors
- Keratoacanthoma, myeloma, plasmablastic lymphoma (strong), primary effusion lymphoma, pyothorax associated lymphoma
Negative staining
- Mature B cells, other lymphomas (even plasmacytoid lymphomas)
Additional references
