CD Markers
CD138



Topic Completed: 1 February 2002

Minor changes: 27 July 2021

Copyright: 2002-2021, PathologyOutlines.com, Inc.

PubMed Search: CD138[title]

Nat Pernick, M.D.
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Cite this page: Pernick N. CD138. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd138.html. Accessed October 24th, 2021.
Definition / general
  • Aka heparan sulfate proteoglycan, syndecan-1
  • Mediates cell adhesion, growth factors; associated with late stage of B cell differentiation
  • Integral membrane protein is a receptor for extracellular matrix
  • Loss of CD138 expression is associated with tumor aggressiveness in squamous cell carcinoma (SCC) of head and neck and larynx; levels also reduced in invasive SCC but not in SCC in situ
Interpretation
  • Membranous staining
Microscopic (histologic) images

Contributed by Yuri Tachibana, M.D.

Chronic endometritis

Positive staining - normal
  • B cell precursors, plasma cells, stratified squamous epithelium
Positive staining - tumors
  • Keratoacanthoma, myeloma, plasmablastic lymphoma (strong), primary effusion lymphoma, pyothorax associated lymphoma
Negative staining
  • Mature B cells, other lymphomas (even plasmacytoid lymphomas)
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