Pathology Outlines

CD Markers
CD150-159

Topic Completed: 1 August 2013

Minor changes: 14 May 2021

Copyright: 2003-2021, PathologyOutlines.com, Inc.

PubMed Search: CD150[title], CD151[title], CD152[title], CD153[title], CD154[title], CD155[title], CD156, BST1, CD158, CD159a, CD159c

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Table of Contents

CD150 | CD151 | CD152 | CD153 | CD154 | CD155 | CD156a | CD156b | CD156c | CD157 | CD158 | CD158a | CD158b | CD159a | CD159c

Cite this page: Pernick N. CD150-159. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd150.html. Accessed June 23rd, 2021.

CD150

Also known as signal lymphocyte activation molecule (SLAM)
Costimulatory molecule on B lymphocytes and dendritic cells
Positive staining - normal: thymocytes, CD45RO positive subpopulation of T cells, B cells, dendritic cells, endothelium

CD151

May modify integrin function or signaling
Positive staining - normal: endothelium, platelets, megakaryocytes, epithelium

CD152

Also known as cytotoxic T lymphocyte associated protein 4, CTLA4
Negative regulator of T cell activation
CTLA4 restriction fragment length polymorphisms are linked to various autoimmune disorders
Shares sequence homology with CD28; also shares ligands CD80 and CD86 with CD28
Positive staining - normal: activated but not resting T cells, activated B cells
Reference: OMIM CD152

CD153

Also known as CD30 ligand
Enhances CD3 activated T lymphocyte proliferation

CD154

Also known as CD40 ligand, CD40L, TNF related activation protein (TRAP)
Regulates B cell function by engaging CD40
Defective gene prevents immunoglobulin class switch and is associated with hyper IgM syndrome, autoimmune hematologic disorders, disorganized nodal follicular architecture and PAS positive plasmacytoid cells containing IgM, lymph nodes without germinal centers, shortened lifespan, often with gastrointestinal cancers (cholangiocarcinoma, hepatocellular carcinoma and adenocarcinoma) and Cryptosporidium parvum infection
Positive staining - normal: T cells

CD155

Also known as polio virus receptor
Involved in intercellular adhesion
Positive staining - normal: embryonic structures giving rise to spinal cord anterior horn motor neurons

CD156a

Also known as ADAM8
May play a role in muscle differentiation
Possible role in neutrophilic extravasation
Stains neutrophils, monocytes

CD156b

Also known as Tumor necrosis factor Alpha Converting Enzyme (TACE), ADAM17
Adhesion structure; releases soluble forms of tumor necrosis factor and transforming growth factor alpha from cells
Stains all cells examined, with pro domain removed

CD156c

Also known as ADAM10
Protein belonging to a superfamily of metalloproteases (Anal Cell Pathol (Amst) 2015;2015:975436)

CD157

Also known as Bone marrow STromal cell antigen 1 (BST1)
Facilitates pre B cell growth
33% homology to CD38
Overexpression may cause polyclonal B cell abnormalities in rheumatoid arthritis
Positive staining - normal: granulocytes, monocytes, B cell progenitors, T cell subpopulations

CD158

Member of KIR (killer cell immunoglobulin like receptor) family, also called killer cell inhibitory receptors
Binding by HLA class I molecules causes inhibition of NK or T cell cytotoxic activity
Melanoma specific cytotoxic T lymphocytes may express KIR and regulate their ability to kill these tumors
Terminology:
- CD158c: KIR2DS6 / KIRX
- CD158d: KIR2DL4
- CD158e1: KIR3DL1 / p70
- CD158e2: KIR3DS1 / p70
- CD158f: KIR2DL5 (Front Immunol 2017;7:698)
- CD158g: KIR2DS5
- CD158h: KIR2DS1 / p50.1
- CD158i: KIR2DS4 / p50.3
- CD158j: KIR2DS2 / p50.2
- CD158k: KIR3DL2 / p140
- CD158z: KIR3DL7 / KIRC1
Positive staining - normal: natural killer cells (NK cells), some T cells

CD158a

Also known as KIR2DL1 / p58.1
Regulates NK cell mediated cytolytic activity
Includes 2 different molecules with inhibitory and activation effects, presumably encoded by different genes of the same family
Positive staining: NK cell subset

CD158b

CD158b1: KIR2DL2 / p58.2
CD158b2: KIR2DL3 / p58.3
Regulates NK cell mediated cytolytic activity
Includes 2 different molecules with inhibitory and activation effects, presumably encoded by different genes of the same family
Positive staining: NK cell subset, rare T cells

CD159a

Also known as NKG2A, killer cell lectin-like receptor subfamily C member 1
Mediates signaling in the killing process by NK cells
Positive staining - normal: NK cells

CD159c

Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by natural killer cells and some cytotoxic T cells (Front Immunol 2018;9:686)
Also known as NKG2C, KLRC2
Positive staining - normal: natural killer cells and CD8+ T cells