Stains & CD markers
CD150-159


Topic Completed: 1 August 2013

Minor changes: 24 June 2021

Copyright: 2003-2021, PathologyOutlines.com, Inc.

PubMed Search: CD150[title], CD151[title], CD152[title], CD153[title], CD154[title], CD155[title], CD156, BST1, CD158, CD159a, CD159c

Nat Pernick, M.D.
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Table of Contents
CD150 | CD151 | CD152 | CD153 | CD154 | CD155 | CD156a | CD156b | CD156c | CD157 | CD158 | CD158a | CD158b | CD159a | CD159c
Cite this page: Pernick N. CD150-159. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd150.html. Accessed October 24th, 2021.
CD150
  • Also known as signal lymphocyte activation molecule (SLAM)
  • Costimulatory molecule on B lymphocytes and dendritic cells
  • Positive staining - normal: thymocytes, CD45RO positive subpopulation of T cells, B cells, dendritic cells, endothelium
CD151
  • May modify integrin function or signaling
  • Positive staining - normal: endothelium, platelets, megakaryocytes, epithelium
CD152
  • Also known as cytotoxic T lymphocyte associated protein 4, CTLA4
  • Negative regulator of T cell activation
  • CTLA4 restriction fragment length polymorphisms are linked to various autoimmune disorders
  • Shares sequence homology with CD28; also shares ligands CD80 and CD86 with CD28
  • Positive staining - normal: activated but not resting T cells, activated B cells
  • Reference: OMIM CD152
CD153
  • Also known as CD30 ligand
  • Enhances CD3 activated T lymphocyte proliferation
CD154
  • Also known as CD40 ligand, CD40L, TNF related activation protein (TRAP)
  • Regulates B cell function by engaging CD40
  • Defective gene prevents immunoglobulin class switch and is associated with hyper IgM syndrome, autoimmune hematologic disorders, disorganized nodal follicular architecture and PAS positive plasmacytoid cells containing IgM, lymph nodes without germinal centers, shortened lifespan, often with gastrointestinal cancers (cholangiocarcinoma, hepatocellular carcinoma and adenocarcinoma) and Cryptosporidium parvum infection
  • Positive staining - normal: T cells
CD155
  • Also known as polio virus receptor
  • Involved in intercellular adhesion
  • Positive staining - normal: embryonic structures giving rise to spinal cord anterior horn motor neurons
CD156a
  • Also known as ADAM8
  • May play a role in muscle differentiation
  • Possible role in neutrophilic extravasation
  • Stains neutrophils, monocytes
CD156b
  • Also known as Tumor necrosis factor Alpha Converting Enzyme (TACE), ADAM17
  • Adhesion structure; releases soluble forms of tumor necrosis factor and transforming growth factor alpha from cells
  • Stains all cells examined, with pro domain removed
CD156c
CD157
  • Also known as Bone marrow STromal cell antigen 1 (BST1)
  • Facilitates pre B cell growth
  • 33% homology to CD38
  • Overexpression may cause polyclonal B cell abnormalities in rheumatoid arthritis
  • Positive staining - normal: granulocytes, monocytes, B cell progenitors, T cell subpopulations
CD158
  • Member of KIR (killer cell immunoglobulin like receptor) family, also called killer cell inhibitory receptors
  • Binding by HLA class I molecules causes inhibition of NK or T cell cytotoxic activity
  • Melanoma specific cytotoxic T lymphocytes may express KIR and regulate their ability to kill these tumors
  • Terminology:
    • CD158c: KIR2DS6 / KIRX
    • CD158d: KIR2DL4
    • CD158e1: KIR3DL1 / p70
    • CD158e2: KIR3DS1 / p70
    • CD158f: KIR2DL5 (Front Immunol 2017;7:698)
    • CD158g: KIR2DS5
    • CD158h: KIR2DS1 / p50.1
    • CD158i: KIR2DS4 / p50.3
    • CD158j: KIR2DS2 / p50.2
    • CD158k: KIR3DL2 / p140
    • CD158z: KIR3DL7 / KIRC1
  • Positive staining - normal: natural killer cells (NK cells), some T cells
CD158a
  • Also known as KIR2DL1 / p58.1
  • Regulates NK cell mediated cytolytic activity
  • Includes 2 different molecules with inhibitory and activation effects, presumably encoded by different genes of the same family
  • Positive staining: NK cell subset
CD158b
  • CD158b1: KIR2DL2 / p58.2
  • CD158b2: KIR2DL3 / p58.3
  • Regulates NK cell mediated cytolytic activity
  • Includes 2 different molecules with inhibitory and activation effects, presumably encoded by different genes of the same family
  • Positive staining: NK cell subset, rare T cells
CD159a
  • Also known as NKG2A, killer cell lectin-like receptor subfamily C member 1
  • Mediates signaling in the killing process by NK cells
  • Positive staining - normal: NK cells
CD159c
  • Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by natural killer cells and some cytotoxic T cells (Front Immunol 2018;9:686)
  • Also known as NKG2C, KLRC2
  • Positive staining - normal: natural killer cells and CD8+ T cells
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