CD Markers
CD30
Copyright: 2002-2019, PathologyOutlines.com, Inc.
PubMed Search: CD30 [title]
CD30
Author: Nat Pernick, M.D.
Topic Completed: 1 January 2011
Minor changes: 14 December 2019
Copyright: 2002-2019, PathologyOutlines.com, Inc.
PubMed Search: CD30 [title]
Table of Contents
Definition / general | Terminology | Pathophysiology | Clinical features | Interpretation | Uses by pathologists | Microscopic (histologic) images | Positive staining - normal | Positive staining - disease | Negative staining | Flow cytometry images | Additional referencesCite this page: Pernick N. CD30. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd30.html. Accessed June 7th, 2020.
Definition / general
- CD30: lymphocyte activation antigen important in diagnosis of classic Hodgkin's lymphoma, anaplastic large cell lymphoma and embryonal carcinoma
- CD30v: variant form of CD30 which retains only the cytoplasmic domain; very little has been published about CD30v
- Note: all content of this topic is about CD30, unless stated otherwise
Terminology
- Also known as Ki-1, Ber-H2
Pathophysiology
- Member of tumor necrosis factor family of cell surface receptors; also a lymphocyte activation antigen
- Overexpression causes constitutive expression of nuclear factor-KB, which is considered the molecular basis for aberrant growth and cytokine expression that causes Hodgkin’s lymphoma (Am J Pathol 2003;163:633)
- Ligand is CD153
- May also be involved in elimination of autoreactive T cells in thymus
Clinical features
- In renal transplants, high serum soluble CD30 levels in graft recipients predicts acute and chronic rejection and graft loss (Am J Transplant 2005;5:1922, Transplant Proc 2005;37:1776, Transplantation 2005;79:1154)
Interpretation
- Membranous and Golgi type staining
- Staining doesn’t work well with prolonged formalin fixation or with B5 fixation
Uses by pathologists
- Confirm diagnosis of anaplastic large cell lymphoma, classic Hodgkin's lymphoma, embryonal carcinoma
- Other lymphoma diagnosis
Microscopic (histologic) images
Images hosted on PathOut server:
Lymphomatoid papulosis
Images hosted on other servers:
Anaplastic large cell lymphoma:
Post liver transplant, FB
Primary cutaneous, F4
Brain tumor, HIV patient
Primary brain tumor, FB
Sarcomatoid variant, F7
CD30+ scalp lesion, FB
Primary bone tumor, F2B
Strong membrane and golgi staining pattern (site unspecified)
Small cell variant, anaplastic large cell lymphoma
Classic Hodgkin lymphoma:
Membrane staining
Left to right: pulmonary, F3B; GE junction, FD; EBV+ ileal tumor, FD; colon, F4b
Membrane and paranuclear staining
Classic Hodgkin lymphoma
Other lymphoma:
Plasmablastic lymphoma, F4
Atypical cells in follicular lymphoma
Positive staining - normal
- Granulocytes, plasma cells (some, Am J Clin Path 1989;91:18)
- Activated B, T and NK cells, monocytes, decidua (Am J Pathol 1994;145:276)
- CD30v: alveolar macrophages (Blood 1996;88:2422)
Positive staining - disease
- Anaplastic large cell lymphoma (systemic or primary cutaneous, 90%), classic Hodgkin lymphoma (Reed-Sternberg cells, J Clin Pathol 2002;55:162)
- Also Reed-Sternberg like cells in follicular lymphoma (Am J Clin Path 2004;122:858, Arch Pathol Lab Med 2001;125:1036)
- Primary mediastinal large B cell lymphoma (usually focal)
- Peripheral T-cell lymphoma (occasional, Am J Surg Pathol 2003;27:1513)
- Sprue-associated lymphoma, Lennert lymphoma (occasional), primary effusion lymphoma (Am J Clin Path 1996;105:221)
- Primary cutaneous CD30+ lymphoproliferative disorders, lymphomatoid papulosis (Blood 2002;100:578) and EBV-associated atypical lymphoproliferative disease mimicking Hodgkin lymphoma (Am J Surg Pathol 2010;34:1715)
- Diffuse large cell lymphoma (variable, usually focal, Am J Surg Pathol 2002;26:1458)
- Plasmablastic lymphoma (Arch Pathol Lab Med 2004;128:581) and plasma cell neoplasms (some)
- Eosinophil rich CD30+ lymphoproliferative disorder of oral mucosa (Am J Clin Path 2004;121:43)
- Sinonasal NK/T cell lymphoma with large cell morphology (focal, Am J Surg Pathol 2000;24:1511)
- Nasal NK/T cell lymphoma in Chinese patients (Hum Pathol 2006;37:54)
- Embryonal carcinoma of testis (100%, but variable intensity, Am J Surg Pathol 2004;28:935)
- Yolk sac tumors (24%, Hum Pathol 1998;29:737), seminoma (6%, Am J Clin Path 2000;113:583)
- Rarely mesothelioma (Arch Pathol Lab Med 2000;124:1077)
- Lymphocytes infected with HIV, HTLV-1, EBV, HHV8, hepatitis B or herpes (Am J Surg Pathol 2006;30:50)
- Also epithelioid inflammatory myofibrolastic sarcoma (Am J Surg Pathol 2011;35:135), nonneoplastic inflammatory cutaneous infiltrates (Am J Surg Pathol 2003;27:912), including arthropod bites, Omenn syndrome (Am J Surg Pathol 1996;20:773)
- CD30v: myeloid and lymphoid malignancies (Am J Pathol 1999;155:2029)
Negative staining
- Nodular lymphocyte predominant Hodgkin lymphoma (Am J Clin Path 2003;119:192)
- Adult T cell leukemia/lymphoma, pre-B ALL, extramedullary myeloid tumors (Am J Surg Pathol 1993;17:1011), follicular dendritic cell tumor, interdigitating dendritic cell sarcoma (Am J Clin Path 2001;115:589)
- Histiocytic sarcoma (Am J Surg Pathol 2004;28:1133), lymphoepithelioma-like carcinoma, melanoma, reticulohistiocytoma (Am J Surg Pathol 2006;30:521), T cell prolymphocytic leukemia (Am J Surg Pathol 2005;29:935)
- >Kikuchi disease / necrotizing lymphadenitis (Am J Surg Pathol 1999;23:1040)
- Systemic mastocytosis (Hum Pathol 2001;32:545)
Flow cytometry images
Images hosted on other servers:
Flow cytometry images of anaplastic large cell lymphoma
Additional references
