CD Markers
CD43


Last author update: 1 January 2011
Last staff update: 3 June 2022

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PubMed Search: CD43

Nat Pernick, M.D.
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Cite this page: Pernick N. CD43. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd43.html. Accessed December 5th, 2022.
Definition / general
  • Pan T cell marker important in T cell and neutrophil adhesion to endothelium
Terminology
  • Also called leukosialin, sialophorin
Pathophysiology
Clinical features
  • Has defective expression in T cells of males with Wiskott-Aldrich syndrome (MIM 301000)
Uses by pathologists
  • Pan T cell marker
  • Diagnosis of myeloid (granulocytic) sarcoma (J Clin Pathol 2005;58:211)
  • Classify subtypes of T cell lymphomas and low grade B cell lymphomas
  • Differentiate pulmonary MALT lymphoma (CD20+ CD43+) from lymphoid hyperplasia (CD43 negative, Am J Surg Pathol 2002;26:76)
Microscopic (histologic) images

Cases #140 and #127

Leukemia cutis

MALT lymphoma of stomach



Images hosted on other servers:
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Mantle cell lymphoma

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Anaplastic large cell lymphoma

Positive staining - normal
Positive staining - disease
Negative staining
  • Colonic epithelium, follicular lymphoma, Hodgkin’s lymphoma, lymphoepithelioma-like thymic carcinoma, primary effusion lymphoma, splenic marginal zone lymphoma
Additional references
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