Cervix
Cytologic features
Transitional (urothelial) metaplasia
Author: Farnaz Hasteh, M.D.
Topic Completed: 1 March 2011
Minor changes: 19 March 2020
Copyright: 2006-2020, PathologyOutlines.com, Inc.
PubMed search: Transitional urothelial metaplasia
Table of Contents
Terminology | Etiology | Clinical features | Cytology description | Cytology images | Positive stains | Negative stains | Differential diagnosis | Additional referencesCite this page: Hasteh F. Transitional (urothelial) metaplasia. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cervixcytologytransitionalmetaplasia.html. Accessed August 3rd, 2020.
Terminology
- Also called immature transitional (urothelial) metaplasia
Etiology
- Associated with atrophy, menopausal women
- May be related to HPV (Cancer 2002;96:250)
Clinical features
- Predominantly in postmenopausal women
Cytology description
- Clusters of cells with streaming, oval, bland nuclei containing longitudinal nuclear grooves
- May have perinuclear halos and wrinkled contours
- No / rare mitotic figures, no cilia, no crowding or nuclear atypia
Cytology images
Images hosted on other servers:
Transitional cell metaplasia
Squamous and transition (urothelial) metaplasia
Positive stains
- Positive for CK13, CK17 and CK18 (Int J Gynecol Pathol 1999;18:125)
Negative stains
- Negative for CK20 (unlike urothelium, which is CK20+, Int J Gynecol Pathol 1999;18:125)
Differential diagnosis
Additional references
