Noninfectious colitis

Behcet's syndrome

Topic Completed: 1 May 2013

Minor changes: 7 December 2020

Copyright: 2003-2021,, Inc.

PubMed Search: behcet's syndrome

Hanni Gulwani, M.B.B.S.
Page views in 2020: 1,510
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Cite this page: Gulwani H. Behcet's syndrome. website. Accessed October 25th, 2021.
Definition / general
  • Multisystem inflammatory disorder of unknown origin, with aphthous stomatitis, genital ulcers, relapsing iritis; also arthritis, cutaneous and vascular disease (eMedicine #1, #2)
  • GI involvement in 10% (ileum, cecum); causes pain, diarrhea, melena; rarely perforation (Surg Today 2003;33:383)
  • More common in region from Mediterranean to eastern Asia
  • 2 / 3 in males
Case reports
  • Steroids
Clinical images

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Punched-out ulcer

Gross description
  • Numerous punched out ulcers of various sizes, shapes and depths in colon
Gross images

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Multiple penetrations


Microscopic (histologic) description
  • Ulcers with neutrophils around ulcer bed, lymphocytic vasculitis in submucosal veins
  • Note: diagnosis is clinical, not histologic
Microscopic (histologic) images

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Loss of normal mucosa

Various images

Differential diagnosis
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