Table of Contents
Definition / general | Epidemiology | Case reports | Treatment | Clinical images | Gross description | Gross images | Microscopic (histologic) description | Microscopic (histologic) images | Differential diagnosisCite this page: Gulwani H. Behcet's syndrome. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/colonbehcet.html. Accessed March 29th, 2024.
Definition / general
- Multisystem inflammatory disorder of unknown origin, with aphthous stomatitis, genital ulcers, relapsing iritis; also arthritis, cutaneous and vascular disease (eMedicine #1, #2)
- GI involvement in 10% (ileum, cecum); causes pain, diarrhea, melena; rarely perforation (Surg Today 2003;33:383)
Epidemiology
- More common in region from Mediterranean to eastern Asia
- 2 / 3 in males
Case reports
- 16 year old girl with colonic Behcet's disease with pyoderma gangrenosum (World J Gastroenterol 2006;12:979)
- 17 year old monozygotic male twins with concordant colonic Behçet's disease(J Gastroenterol 2005;40:421)
- 17 year old boy with colonic perforation in Behcet's syndrome (World J Gastroenterol 2008;14:6578)
- 20 year old man with Behçet's disease with multiple colon perforations (Turk J Gastroenterol 2010;21:324)
- 21 year old man with multiple perforations along the transverse colon (Clinics (Sao Paulo) 2009;64:1231)
- 29 year old woman with severe colitis (Am J Surg Pathol 1986;10:888)
- 34 year old man with case resembling inflammatory bowel disease (Intern Med 2004;43:243)
- 37 year old woman with case with longitudinal ulcers and granulomas resembling Crohn's (J Gastroenterol Hepatol 2002;17:105)
- 77 year old man with colon cancer arising in an ulcer scar due to intestinal Behçet's disease (Intern Med 2011;50:429)
Treatment
- Steroids
Gross description
- Numerous punched out ulcers of various sizes, shapes and depths in colon
Microscopic (histologic) description
- Ulcers with neutrophils around ulcer bed, lymphocytic vasculitis in submucosal veins
- Note: diagnosis is clinical, not histologic
Differential diagnosis